dbPTM

HINT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HINT2_HUMAN
UniProt AC	Q9BX68
Protein Name	Histidine triad nucleotide-binding protein 2, mitochondrial {ECO:0000305}
Gene Name	HINT2 {ECO:0000312\|HGNC:HGNC:18344}
Organism	Homo sapiens (Human).
Sequence Length	163
Subcellular Localization	Mitochondrion .
Protein Description	Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity..
Protein Sequence	MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	TPGGAAPTIFSRILD CCCCCCCHHHHHHHC	29.90	-
57	Phosphorylation	GAAPTIFSRILDKSL CCCCHHHHHHHCCCC	17.98	-
58	Methylation	AAPTIFSRILDKSLP CCCHHHHHHHCCCCC	23.81	115478505
75	Glutathionylation	ILYEDQQCLVFRDVA EEECCCEEEEEEECC	2.66	22555962
119	Acetylation	GHLLLVAKQTAKAEG HHHHHHHHHHHHHCC	40.48	-
119	Neddylation	GHLLLVAKQTAKAEG HHHHHHHHHHHHHCC	40.48	32015554
119	Ubiquitination	GHLLLVAKQTAKAEG HHHHHHHHHHHHHCC	40.48	32015554
123	Neddylation	LVAKQTAKAEGLGDG HHHHHHHHHCCCCCC	50.81	32015554
123	Ubiquitination	LVAKQTAKAEGLGDG HHHHHHHHHCCCCCC	50.81	32015554
123	Succinylation	LVAKQTAKAEGLGDG HHHHHHHHHCCCCCC	50.81	27452117
139	Acetylation	RLVINDGKLGAQSVY EEEEECCCCCCEEEE	46.76	-
146	Phosphorylation	KLGAQSVYHLHIHVL CCCCEEEEEEEEEEE	12.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HINT2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HINT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HINT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HINT2_HUMAN

Related Literatures of Post-Translational Modification