HIG2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIG2A_HUMAN
• UniProt AC: Q9BW72
• Protein Name: HIG1 domain family member 2A, mitochondrial
• Gene Name: HIGD2A
• Organism: Homo sapiens (Human).
• Sequence Length: 106
• Subcellular Localization: Mitochondrion membrane ; Multi-pass membrane protein . Mitochondrion inner membrane .
• Protein Description: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes..
• Protein Sequence: MATPGPVIPEVPFEPSKPPVIEGLSPTVYRNPESFKEKFVRKTRENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLGLAVTAMKSRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATPGPVIP ------CCCCCCCCC	23.62	25944712
3	Phosphorylation	-----MATPGPVIPE -----CCCCCCCCCC	27.72	18491316
74	Dimethylation	FHRGNSQRSQLMMRT CCCCCCHHHHHHHHH	26.62	-
74	Methylation	FHRGNSQRSQLMMRT CCCCCCHHHHHHHHH	26.62	24412339
89	Phosphorylation	RIAAQGFTVAAILLG HHHHCCHHHHHHHHH	18.96	22210691
100	Phosphorylation	ILLGLAVTAMKSRP- HHHHHHHHHHHCCC-	18.54	24719451
102	Sulfoxidation	LGLAVTAMKSRP--- HHHHHHHHHCCC---	2.71	28183972
104	Phosphorylation	LAVTAMKSRP----- HHHHHHHCCC-----	36.38	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIG2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIG2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIG2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330