dbPTM

HFA4A_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HFA4A_ARATH
UniProt AC	O49403
Protein Name	Heat stress transcription factor A-4a
Gene Name	HSFA4A
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	401
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE)..
Protein Sequence	MDENNHGVSSSSLPPFLTKTYEMVDDSSSDSIVSWSQSNKSFIVWNPPEFSRDLLPRFFKHNNFSSFIRQLNTYGFRKADPEQWEFANDDFVRGQPHLMKNIHRRKPVHSHSLPNLQAQLNPLTDSERVRMNNQIERLTKEKEGLLEELHKQDEEREVFEMQVKELKERLQHMEKRQKTMVSFVSQVLEKPGLALNLSPCVPETNERKRRFPRIEFFPDEPMLEENKTCVVVREEGSTSPSSHTREHQVEQLESSIAIWENLVSDSCESMLQSRSMMTLDVDESSTFPESPPLSCIQLSVDSRLKSPPSPRIIDMNCEPDGSKEQNTVAAPPPPPVAGANDGFWQQFFSENPGSTEQREVQLERKDDKDKAGVRTEKCWWNSRNVNAITEQLGHLTSSERS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	HRRKPVHSHSLPNLQ HHCCCCCCCCCCCHH	18.27	19880383
112	Phosphorylation	RKPVHSHSLPNLQAQ CCCCCCCCCCCHHHH	48.84	23111157
237	Phosphorylation	VVVREEGSTSPSSHT EEEECCCCCCCCCCC	29.05	25561503
238	Phosphorylation	VVREEGSTSPSSHTR EEECCCCCCCCCCCC	56.36	25561503
239	Phosphorylation	VREEGSTSPSSHTRE EECCCCCCCCCCCCH	25.20	25561503
306	Phosphorylation	SVDSRLKSPPSPRII ECCCCCCCCCCCCEE	46.78	25561503
309	Phosphorylation	SRLKSPPSPRIIDMN CCCCCCCCCCEEEEE	30.14	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HFA4A_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HFA4A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HFA4A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
HFA4A_ARATH	HSF A4A	physical	24676858

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HFA4A_ARATH

Related Literatures of Post-Translational Modification