| UniProt ID | HESX1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UBX0 | |
| Protein Name | Homeobox expressed in ES cells 1 | |
| Gene Name | HESX1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 185 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.. | |
| Protein Sequence | MSPSLQEGAQLGENKPSTCSFSIERILGLDQKKDCVPLMKPHRPWADTCSSSGKDGNLCLHVPNPPSGISFPSVVDHPMPEERASKYENYFSASERLSLKRELSWYRGRRPRTAFTQNQIEVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKLKRSHRESQFLMAKKNFNTNLLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 87 | Phosphorylation | PEERASKYENYFSAS CHHHHHHHHCCCCHH | 13.60 | - | |
| 90 | Phosphorylation | RASKYENYFSASERL HHHHHHCCCCHHHHH | 6.23 | - | |
| 94 | Phosphorylation | YENYFSASERLSLKR HHCCCCHHHHHHHHH | 23.27 | - | |
| 104 | Phosphorylation | LSLKRELSWYRGRRP HHHHHHHHHHCCCCC | 19.80 | 24719451 | |
| 106 | Phosphorylation | LKRELSWYRGRRPRT HHHHHHHHCCCCCCC | 10.38 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HESX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HESX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HESX1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NCOR1_HUMAN | NCOR1 | physical | 9751061 | |
| TLE1_HUMAN | TLE1 | physical | 11731482 | |
| KDM1A_HUMAN | KDM1A | physical | 23455924 | |
| ANM6_HUMAN | PRMT6 | physical | 23455924 | |
| RET4_HUMAN | RBP4 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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