HEPS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEPS_HUMAN
• UniProt AC: P05981
• Protein Name: Serine protease hepsin
• Gene Name: HPN
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Apical cell membrane ; Single-pass type II membrane protein .
• Protein Description: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. [PubMed: 21875933]
• Protein Sequence: MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	N-linked_Glycosylation	DVRTAGANGTSGFFC CCEECCCCCCCCEEE	54.05	19159218
341	Phosphorylation	PKMFCAGYPEGGIDA CCEEECCCCCCCCCC	4.60	-
353	Phosphorylation	IDACQGDSGGPFVCE CCCCCCCCCCCEECC	53.10	-
362	Phosphorylation	GPFVCEDSISRTPRW CCEECCCCCCCCCCE	10.52	-
364	Phosphorylation	FVCEDSISRTPRWRL EECCCCCCCCCCEEE	33.77	-
386	Ubiquitination	TGCALAQKPGVYTKV CCCHHHCCCCEEEEH	37.82	-
392	Ubiquitination	QKPGVYTKVSDFREW CCCCEEEEHHHHHHH	23.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEPS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEPS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEPS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	19911255

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112, AND MASSSPECTROMETRY.
PubMed: 19159218