HEM3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM3_SCHPO
• UniProt AC: Q09899
• Protein Name: Porphobilinogen deaminase
• Gene Name: hem3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 336
• Protein Description: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps..
• Protein Sequence: MPSCTSFPIGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTRELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPPGSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVALALLKNGAGPILEEHQRSSDSEESLKNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
251	S-(dipyrrolylmethanemethyl)cysteine	MKRLQGGCAIPIGVQ HHHHCCCCCCCCCCC	3.87	-
251	Pyrrolylation	MKRLQGGCAIPIGVQ HHHHCCCCCCCCCCC	3.87	-
326	Phosphorylation	ILEEHQRSSDSEESL HHHHHHHCCCCHHHH	31.74	28889911
327	Phosphorylation	LEEHQRSSDSEESLK HHHHHHCCCCHHHHH	47.55	28889911
329	Phosphorylation	EHQRSSDSEESLKNY HHHHCCCCHHHHHCC	45.25	28889911
332	Phosphorylation	RSSDSEESLKNY--- HCCCCHHHHHCC---	40.36	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HEM3_SCHPO	hem3	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND SER-329, ANDMASS SPECTROMETRY.
PubMed: 18257517