HAL4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAL4_SCHPO
• UniProt AC: O14019
• Protein Name: Serine/threonine-protein kinase hal4
• Gene Name: hal4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 636
• Subcellular Localization: Cytoplasm .
• Protein Description: Promotes K(+) uptake, by the potassium transporter trk1-trk2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+)..
• Protein Sequence: MGEKDKLHEISSKFASLGLGSLKSTPKARETTEPPPPSSQQPPSTPNGKEAASPSALKQNVRPSLNSVQQTPASIDAVASSSNVSLQSQQPLSKPVVSSKPNQTTAMPPPSNNPSRHVSSTSNKPAAVSPNPAAHHAELPSGSVPPSASVSRANSTATTTPHKAGVVSNPAAANVHVLSVAASPNPSTPSNGPAPVSTTATPSRNPVTRLQRIFSQNSVSRQNSRTGRGAAVANTEETNSTGGSETGGAANSSSTSNPSSAKWSRFTVYDDASHTHQLRPARRQEKLGKMLKDFLAGNSKKREEERIAKEAADAQHQLSLVQSWINGYGQEKLADKKDPAKVSASFVEKYGRCQEVIGRGAFGVVRIAHKVDPQNSGSETLYAVKEFRRKPAESQKKYTKRLTSEFCISSSLRHPNVIHTLDLIQDGKGDYCEVMELCSGGDLYTLIMAAGRLEPMEADCFFKQLMRGVDYLHDMGVAHRDLKPENLLLTVSGSLKITDFGNGECFRMAWEKEAHMTCGLCGSAPYIAPEEYTESEFDPRAVDVWACGVIYMAMRTGRHLWRVAKKSEDEYYSRYLMDRKNESGYEPIEMLERSRCRNTLYNILHPNPTYRLTAKQIMKSEWVRSITLCEAGNAGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	FASLGLGSLKSTPKA HHHCCCCCCCCCCCC	37.35	25720772
44	Phosphorylation	PSSQQPPSTPNGKEA CCCCCCCCCCCCCCC	64.28	24763107
45	Phosphorylation	SSQQPPSTPNGKEAA CCCCCCCCCCCCCCC	26.92	21712547
74	Phosphorylation	SVQQTPASIDAVASS CCCCCCHHHHHHHHC	23.39	21712547
80	Phosphorylation	ASIDAVASSSNVSLQ HHHHHHHHCCCCCCC	27.92	21712547
85	Phosphorylation	VASSSNVSLQSQQPL HHHCCCCCCCCCCCC	25.58	21712547
141	Phosphorylation	AHHAELPSGSVPPSA CCCCCCCCCCCCCCC	57.22	21712547
147	Phosphorylation	PSGSVPPSASVSRAN CCCCCCCCCCCCCCC	27.40	21712547
149	Phosphorylation	GSVPPSASVSRANST CCCCCCCCCCCCCCC	25.59	27738172
151	Phosphorylation	VPPSASVSRANSTAT CCCCCCCCCCCCCCC	24.15	21712547
155	Phosphorylation	ASVSRANSTATTTPH CCCCCCCCCCCCCCC	20.59	21712547
179	Phosphorylation	AANVHVLSVAASPNP HCCEEEEEEEECCCC	14.50	29996109
183	Phosphorylation	HVLSVAASPNPSTPS EEEEEEECCCCCCCC	18.57	29996109
197	Phosphorylation	SNGPAPVSTTATPSR CCCCCCCCCCCCCCC	20.98	27738172
215	Phosphorylation	TRLQRIFSQNSVSRQ HHHHHHHCCCCCCCC	26.53	28889911
218	Phosphorylation	QRIFSQNSVSRQNSR HHHHCCCCCCCCCCC	17.52	28889911
220	Phosphorylation	IFSQNSVSRQNSRTG HHCCCCCCCCCCCCC	28.15	29996109
226	Phosphorylation	VSRQNSRTGRGAAVA CCCCCCCCCCCCEEE	30.93	25720772
238	Phosphorylation	AVANTEETNSTGGSE EEECCCCCCCCCCCC	28.39	28889911
240	Phosphorylation	ANTEETNSTGGSETG ECCCCCCCCCCCCCC	35.53	25720772
241	Phosphorylation	NTEETNSTGGSETGG CCCCCCCCCCCCCCC	47.86	28889911
244	Phosphorylation	ETNSTGGSETGGAAN CCCCCCCCCCCCCCC	33.07	25720772
252	Phosphorylation	ETGGAANSSSTSNPS CCCCCCCCCCCCCCC	22.42	25720772
253	Phosphorylation	TGGAANSSSTSNPSS CCCCCCCCCCCCCCC	37.13	25720772
299	Phosphorylation	KDFLAGNSKKREEER HHHHHCCCCHHHHHH	38.34	28889911
323	Phosphorylation	HQLSLVQSWINGYGQ HHHHHHHHHHCCCCH	23.57	24763107
345	Phosphorylation	DPAKVSASFVEKYGR CHHHCCHHHHHHHCC	23.48	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAL4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAL4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAL4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOG1_SCHPO	sty1	genetic	15870269
HOG1_SCHPO	sty1	physical	15870269
TRK1_SCHPO	trk1	genetic	15870269

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218; THR-238; THR-241AND SER-299, AND MASS SPECTROMETRY.
PubMed: 18257517