| UniProt ID | HAIR_MOUSE | |
|---|---|---|
| UniProt AC | Q61645 | |
| Protein Name | Lysine-specific demethylase hairless | |
| Gene Name | Hr | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1182 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity).. | |
| Protein Sequence | MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLRHGALCLGEPAPFWRGVLSTPDSWLPPGFLQGPKDTLSLVEGEGPRNGERKGSWLGGKEGLRWKEAMLAHPLAFCGPACPPRYGPLIPEHSGGHPKSDPVAFRPLHCPFLLETKILERAPFWVPTCLPPYLMSSLPPERPYDWPLAPNPWVYSGSQPKVPSAFGLGSKGFYHKDPNILRPAKEPLAESGMLGLAPGGHLQQACESEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPRAPWPSCPPGLVHSLGNIWAGPGSNSLGYQLGPPATPRCPSPGPPTPPGGCCSSHLPAREGDLGPCRKCQDSPEGGSSGPGESSEERNKADSRACPPSHHTKLKKTWLTRHSEQFECPGGCSGKEESPATGLRALKRAGSPEVQGASRGPAPKRPSHPFPGTGRQGARAWQETPETIIGSKAEAEQQEEQRGPRDGRIRLQESRLVDTSCQHHLAGVTQCQSCVQAAGEVGVLTGHSQKSRRSPLEEKQLEEEDSSATSEEGGGGPGPEASLNKGLAKHLLSGLGDRLCRLLRKEREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIAGAGKNREKTGSQEQHTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRGHCFCQVDARVWAPGDGGQQKEPTEKTPPTPQPSCNGDSNRTKDIKEETPDSTESPAEDGAGRSPLPCPSLCELLASTAVKLCLGHDRIHMAFAPVTPALPSDDRITNILDSIIAQVVERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTRLSPPGALLWLQEPRPKHGFHLFQEHWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTNLDSTAFWEGFSHPETRPKLDEGSVLLLHRTLGDKDASRVQNLASSLPLPEYCAHQGKLNLASYLPLGLTLHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSGLDGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLYHQGASLPPDHRMLYAQMDRAVFQAVKAAVGALQEAK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MESMPSFLKD -----CCCCCCHHCC | 48.10 | 26745281 | |
| 6 | Phosphorylation | --MESMPSFLKDTPA --CCCCCCHHCCCCH | 34.27 | 26745281 | |
| 89 | Phosphorylation | RNGERKGSWLGGKEG CCCCCCCCCCCCCCC | 23.35 | 28059163 | |
| 345 | Phosphorylation | PCRKCQDSPEGGSSG CCCCCCCCCCCCCCC | 10.04 | 23375375 | |
| 409 | Acetylation | ATGLRALKRAGSPEV HHHHHHHHHCCCCCC | 38.94 | 22902405 | |
| 413 | Phosphorylation | RALKRAGSPEVQGAS HHHHHCCCCCCCCCC | 19.53 | 23375375 | |
| 828 | Phosphorylation | KGLSLPLSPVRTRLS CCCCCCCCCCCCCCC | 21.29 | 27180971 | |
| 832 | Phosphorylation | LPLSPVRTRLSPPGA CCCCCCCCCCCCCCC | 35.87 | 21454597 | |
| 938 | Acetylation | LHRTLGDKDASRVQN EECCCCCCCHHHHHH | 54.09 | 22902405 | |
| 966 | Phosphorylation | QGKLNLASYLPLGLT CCCCCHHHHCCCCCE | 30.30 | - | |
| 967 | Phosphorylation | GKLNLASYLPLGLTL CCCCHHHHCCCCCEE | 13.51 | - | |
| 989 | Phosphorylation | WAAYGVNSHRGHLGT HHHHCCCCCCCCCCC | 16.50 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HAIR_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HAIR_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HAIR_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HAIR_MOUSE | Hr | physical | 20211142 | |
| RORB_MOUSE | Rorb | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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