GUTR1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GUTR1_DROME
• UniProt AC: Q9NDM2
• Protein Name: Protein trapped in endoderm-1
• Gene Name: Tre1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 392
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium..
• Protein Sequence: MDQDMGMATGYFQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYRVAYYKIFALLKFWGEPLSPMPSRNYHQSKNSKELSGVIRSTPLFHAVQKNSINQMCQTYSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
298	N-linked_Glycosylation	NVVDDERNTSYPWLH HCCCCCCCCCCCHHH	31.18	-
356	Phosphorylation	SPMPSRNYHQSKNSK CCCCCCCCCCCCCCH	10.50	23607784
359	Phosphorylation	PSRNYHQSKNSKELS CCCCCCCCCCCHHHC	22.08	19429919
362	Phosphorylation	NYHQSKNSKELSGVI CCCCCCCCHHHCHHH	31.10	19429919
366	Phosphorylation	SKNSKELSGVIRSTP CCCCHHHCHHHHCCH	31.91	19429919
371	Phosphorylation	ELSGVIRSTPLFHAV HHCHHHHCCHHHHHH	24.21	19429919
372	Phosphorylation	LSGVIRSTPLFHAVQ HCHHHHCCHHHHHHH	17.73	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GUTR1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GUTR1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GUTR1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAO_DROME	Galphao	physical	22178499

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-362; SER-366AND THR-372, AND MASS SPECTROMETRY.
PubMed: 18327897