dbPTM

GTDC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GTDC1_HUMAN
UniProt AC	Q4AE62
Protein Name	Glycosyltransferase-like domain-containing protein 1
Gene Name	GTDC1
Organism	Homo sapiens (Human).
Sequence Length	458
Subcellular Localization
Protein Description
Protein Sequence	MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRARTSALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKCQVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNFNSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGGVDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEAKKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	KWHWRARTSALYFSQ CCCEEEECCEEEECC	19.84	22210691
45	Phosphorylation	WHWRARTSALYFSQT CCEEEECCEEEECCC	15.66	22210691
50	Phosphorylation	RTSALYFSQTIPISE ECCEEEECCCCCCCH	16.92	22210691
52	Phosphorylation	SALYFSQTIPISEHY CEEEECCCCCCCHHH	27.76	22210691
96	Phosphorylation	FHENQLIYPVKKCQE EECCCEEEECHHHHH	15.57	-
164	Phosphorylation	RPKCQVIYFPIRFPD CCCCEEEEEEECCCC	12.40	26437602
300	Phosphorylation	EHDKDPESFFKVLMH CCCCCHHHHHHHHHH	41.18	27251275
350	Phosphorylation	LHWGYLPSKDDYFQV CCCEECCCCCCHHHH	46.23	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GTDC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GTDC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GTDC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GTDC1_HUMAN

Related Literatures of Post-Translational Modification