GRM4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM4_RAT
• UniProt AC: P31423
• Protein Name: Metabotropic glutamate receptor 4
• Gene Name: Grm4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 912
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity..
• Protein Sequence: MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	N-linked_Glycosylation	NDPDLLPNITLGARI CCCCCCCCCCHHHHH	39.59	-
301	N-linked_Glycosylation	LEAARRANQTGHFFW HHHHHHHHCCCCEEE	37.83	-
454	N-linked_Glycosylation	LKYIRNVNFSGIAGN HHHHHCCCCCCCCCC	28.99	-
475	Phosphorylation	NGDAPGRYDIYQYQL CCCCCCCEEEEEEEC	16.77	-
480	Phosphorylation	GRYDIYQYQLRNGSA CCEEEEEEECCCCCC	7.79	-
484	N-linked_Glycosylation	IYQYQLRNGSAEYKV EEEEECCCCCCEEEE	58.31	-
489	Phosphorylation	LRNGSAEYKVIGSWT CCCCCCEEEEEEEEC	15.40	-
569	N-linked_Glycosylation	YDMRPTENRTSCQPI CCCCCCCCCCCCEEE	55.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIAS1_MOUSE	Pias1	physical	21288202
PIAS3_HUMAN	PIAS3	physical	21288202
CBX4_HUMAN	CBX4	physical	21288202
UBC9_HUMAN	UBE2I	physical	21288202

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.