GRIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIP2_HUMAN
• UniProt AC: Q9C0E4
• Protein Name: Glutamate receptor-interacting protein 2 {ECO:0000305}
• Gene Name: GRIP2 {ECO:0000312|HGNC:HGNC:23841}
• Organism: Homo sapiens (Human).
• Sequence Length: 1043
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons..
• Protein Sequence: MLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSSRAPRSPGPSSPRML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	SLACRRQSIPEEFRG HHHHHHCCCCHHHCC	38.00	26657352
47	Phosphorylation	PEEFRGITVVELIKK CHHHCCEEEEEEHHH	22.71	23312004
67	Phosphorylation	GLTISGGTDKDGKPR EEEEECCCCCCCCCC	43.32	-
98	Phosphorylation	NIGDYIRSVNGIHLT CHHHHHHHCCCEECE	15.46	24719451
105	Phosphorylation	SVNGIHLTRLRHDEI HCCCEECEECCHHHH	17.31	24719451
114	Phosphorylation	LRHDEIITLLKNVGE CCHHHHHHHHHHCCC	31.53	24719451
192	Phosphorylation	GPADREGSLKVGDRL CCCCCCCCCCCCCEE	21.92	16674116
195	Phosphorylation	DREGSLKVGDRLLSV CCCCCCCCCCEEEEE	13.46	24719451
202	Phosphorylation	VGDRLLSVDGIPLHG CCCEEEEECCEECCC	8.67	24719451
211	Phosphorylation	GIPLHGASHATALAT CEECCCHHHHHHHHH	20.46	24719451
417	Phosphorylation	PRGSQPMSPRTTMGR CCCCCCCCCCCCHHH	20.22	26437602
516	Phosphorylation	LSINGIATEDGTMEE EEECCEECCCCCHHH	32.46	28674151
571	Phosphorylation	RSVELGITISSASRK CEEEEEEEEECCCCC	17.01	28152594
573	Phosphorylation	VELGITISSASRKRG EEEEEEEECCCCCCC	15.94	28152594
574	Phosphorylation	ELGITISSASRKRGE EEEEEEECCCCCCCC	26.81	28152594
576	O-linked_Glycosylation	GITISSASRKRGEPL EEEEECCCCCCCCCE	40.04	30379171
576	Phosphorylation	GITISSASRKRGEPL EEEEECCCCCCCCCE	40.04	28152594
592	Phosphorylation	ISDIKKGSVAHRTGT EEECCCCCCCCCCCC	25.63	-
597	Phosphorylation	KGSVAHRTGTLEPGD CCCCCCCCCCCCCCC	25.34	-
599	Phosphorylation	SVAHRTGTLEPGDKL CCCCCCCCCCCCCEE	27.60	-
661	Methylation	SYTVELKRYGGPLGI EEEEEEEECCCCEEE	48.21	-
717	Phosphorylation	SLKGRPLSEAIHLLQ EECCCCHHHHHHHHH	27.88	-
824	Phosphorylation	RPGWLRGSPPPTEPR CCCCCCCCCCCCCCC	28.00	26437602
824	O-linked_Glycosylation	RPGWLRGSPPPTEPR CCCCCCCCCCCCCCC	28.00	30379171
857	Phosphorylation	EDDWEPPTSPAPGPA CCCCCCCCCCCCCCC	59.04	29759185
858	Phosphorylation	DDWEPPTSPAPGPAR CCCCCCCCCCCCCCC	25.49	29759185
935	Phosphorylation	MEELLLPTPLEMHKV HHHHHCCCCCEEEEE	40.24	26853621
1034	Phosphorylation	HSSRAPRSPGPSSPR CCCCCCCCCCCCCCC	32.90	23312004
1038	Phosphorylation	APRSPGPSSPRML-- CCCCCCCCCCCCC--	59.91	20363803
1039	Phosphorylation	PRSPGPSSPRML--- CCCCCCCCCCCC---	21.47	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIPA1_HUMAN	PPFIA1	physical	12629171
GIT1_HUMAN	GIT1	physical	12629171

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.