GRIK5_HUMAN - dbPTM
GRIK5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRIK5_HUMAN
UniProt AC Q16478
Protein Name Glutamate receptor ionotropic, kainate 5
Gene Name GRIK5
Organism Homo sapiens (Human).
Sequence Length 980
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein.
Protein Description Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD..
Protein Sequence MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationIVAFASPSCQVLSSL
HHHHHCCHHHHHHHH		18.0626434776
22PhosphorylationSPSCQVLSSLRMAAI
CCHHHHHHHHHHHHH		28.5926434776
23PhosphorylationPSCQVLSSLRMAAIL
CHHHHHHHHHHHHHC		18.8125954137
135PhosphorylationLQYLRFASVSLYPSN
CEEEEEEEEECCCCC		14.9929759185
137PhosphorylationYLRFASVSLYPSNED
EEEEEEEECCCCCHH		21.4929759185
139PhosphorylationRFASVSLYPSNEDVS
EEEEEECCCCCHHHH		9.3429759185
141PhosphorylationASVSLYPSNEDVSLA
EEEECCCCCHHHHHH		39.0229759185
155PhosphorylationAVSRILKSFNYPSAS
HHHHHHHHCCCCCHH		18.4524719451
162PhosphorylationSFNYPSASLICAKAE
HCCCCCHHHHHHHHH		23.7024719451
187PhosphorylationGFLISKETLSVRMLD
HHCCCCCCEEEEECC		28.2429759185
189PhosphorylationLISKETLSVRMLDDS
CCCCCCEEEEECCCC		18.3329759185
200PhosphorylationLDDSRDPTPLLKEIR
CCCCCCCCHHHHHHC		30.7524719451
219N-linked_GlycosylationSTIIIDANASISHLI
CEEEEECCCCHHHHH		30.39UniProtKB CARBOHYD
271N-linked_GlycosylationILGFSMFNTSHPFYP
CCCEECCCCCCCCCH		31.84UniProtKB CARBOHYD
285N-linked_GlycosylationPEFVRSLNMSWRENC
HHHHHHCCCHHHHCC		24.56UniProtKB CARBOHYD
316PhosphorylationDAVHVVVSAVRELNR
HHHHHHHHHHHHHCC		14.9426074081
322N-linked_GlycosylationVSAVRELNRSQEIGV
HHHHHHHCCCCCCCC		36.48UniProtKB CARBOHYD
355PhosphorylationNYLRMVEYDGLTGRV
HHHHHHCCCCCCCEE		12.14-
359PhosphorylationMVEYDGLTGRVEFNS
HHCCCCCCCEEEECC		28.59-
372N-linked_GlycosylationNSKGQRTNYTLRILE
CCCCCCCEEEEEEHH		29.95UniProtKB CARBOHYD
374PhosphorylationKGQRTNYTLRILEKS
CCCCCEEEEEEHHHH		16.1924719451
394N-linked_GlycosylationEIGVWYSNRTLAMNA
EEEEEECCCEEEECC		25.84UniProtKB CARBOHYD
396PhosphorylationGVWYSNRTLAMNATT
EEEECCCEEEECCEE		24.1020071362
400N-linked_GlycosylationSNRTLAMNATTLDIN
CCCEEEECCEEECEE		28.64UniProtKB CARBOHYD
402PhosphorylationRTLAMNATTLDINLS
CEEEECCEEECEEHH		23.9220071362
403PhosphorylationTLAMNATTLDINLSQ
EEEECCEEECEEHHH		21.7420071362
407N-linked_GlycosylationNATTLDINLSQTLAN
CCEEECEEHHHHHCC		33.05UniProtKB CARBOHYD
414N-linked_GlycosylationNLSQTLANKTLVVTT
EHHHHHCCCEEEEEE		40.74UniProtKB CARBOHYD
478N-linked_GlycosylationLYGAPEPNGSWTGMV
CCCCCCCCCCCCHHH		56.31UniProtKB CARBOHYD
480PhosphorylationGAPEPNGSWTGMVGE
CCCCCCCCCCHHHHH		28.27-
482PhosphorylationPEPNGSWTGMVGELI
CCCCCCCCHHHHHHH		19.66-
644PhosphorylationANLAAFLTVQRMEVP
CHHHHHHHEEEECCC		14.2424719451
735N-linked_GlycosylationYHRRLNCNLTQIGGL
HHHHHCCCCCCCCCC		45.08-
833PhosphorylationFIWSTRRSAESEEVS
HHHHHCCCCCCHHHH		32.8528387310
840PhosphorylationSAESEEVSVCQEMLQ
CCCCHHHHHHHHHHH		22.0628387310
876PhosphorylationGPSRALLSLRAVREM
CHHHHHHHHHHHHHH		19.3624719451
891PhosphorylationRLSNGKLYSAGAGGD
HHHCCCEEECCCCCC		10.4425884760
945PhosphorylationRIQALRASGAGAPPR
HHHHHHHCCCCCCCC		23.8123403867
962PhosphorylationGVPAEATSPPRPRPG
CCCCCCCCCCCCCCC		39.7032142685
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRIK5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRIK5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRIK5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRID2_HUMANGRID2physical
12573530
DLG4_HUMANDLG4physical
11279111
DLG4_HUMANDLG4physical
9808460
DLG3_HUMANDLG3physical
9808460
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRIK5_HUMAN

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Related Literatures of Post-Translational Modification

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