dbPTM

GPR12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPR12_HUMAN
UniProt AC	P47775
Protein Name	G-protein coupled receptor 12
Gene Name	GPR12
Organism	Homo sapiens (Human).
Sequence Length	334
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production..
Protein Sequence	MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	N-linked_Glycosylation	MNEDLKVNLSGLPRD CCCCCCCCCCCCCHH	27.23	UniProtKB CARBOHYD
24	N-linked_Glycosylation	LDAAAAENISAAVSS HHHHHHHCHHHHHHC	28.87	UniProtKB CARBOHYD
243	Phosphorylation	HFLATSHYVTTRKGV HHHHCCCCCCCCCCH	10.16	-
317	S-palmitoylation	KALCLICCGCIPSSL HHHHHHHHCCCHHHH	3.85	-
330	Phosphorylation	SLAQRARSPSDV--- HHHHHCCCCCCC---	27.98	-
332	Phosphorylation	AQRARSPSDV----- HHHCCCCCCC-----	52.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPR12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPR12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPR12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPR12_HUMAN

Related Literatures of Post-Translational Modification