dbPTM

GNRHR_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GNRHR_RAT
UniProt AC	P30969
Protein Name	Gonadotropin-releasing hormone receptor
Gene Name	Gnrhr
Organism	Rattus norvegicus (Rat).
Sequence Length	327
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system..
Protein Sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MANNASLEQDQ ----CCCCCCHHCHH	22.74	-
18	N-linked_Glycosylation	QNHCSAINNSIPLTQ HCHHHHHHCCCCCCC	35.59	-
102	N-linked_Glycosylation	MPLDGMWNITVQWYA EECCCCCEEEEEEHH	15.91	-
140	Phosphorylation	VVISLDRSLAVTQPL HHHCCCHHHCCCCCC	21.98	28825834
153	Phosphorylation	PLAVQSKSKLERSMT CCHHCCHHHHHHHHH	47.95	28825834

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GNRHR_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GNRHR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GNRHR_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
GNRHR_RAT	Gnrhr	physical	11278883

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GNRHR_RAT

Related Literatures of Post-Translational Modification