GNOM_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNOM_ARATH
• UniProt AC: Q42510
• Protein Name: ARF guanine-nucleotide exchange factor GNOM
• Gene Name: GN
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1451
• Subcellular Localization: Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Soluble and partially membrane-bound.
• Protein Description: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting. Acts as the major regulator of endosomal vesicle trafficking but is also involved in the endocytosis process. Could function redundantly with GNL1 in the retrograde Golgi to endoplasmic reticulum trafficking. Regulates vesicle trafficking required for the coordinated polar localization of auxin efflux carriers which in turn determines the direction of auxin flow. Mediates the sorting of PIN1 from endosomal compartments to the basal plasma membrane and the polarization of PIN3 to the bottom side of hypocotyl endodermal cells. Involved in the specification of apical-basal pattern formation in the early embryo and during root formation. Required for correct cell wall organization leading to normal cell adhesion during seedling development. Plays also an essential role in hydrotropism of seedling roots..
• Protein Sequence: MGRLKLHSGIKAIEEEPEDFECTDSSNTTTLACMIDTEIAAVLAVMRRNVRWGGRYMSGDDQLEHSLIQSLKALRKQVFSWNQPWHTISPMLYLQPFLDVIRSDETGAPITSIALSSVYKILNLNVIDQNTANIEDAMHLVVDSVTSCRFEVTDPASEEVVLMKILQVLLACMKNKASVMLSNQHVCTVVNTCFRVVHQAGMKGELLQRVARHTMHELVRCIFSHLPDVERTETTLVNRAGSIKQEKAGVDSDYAIVSKPVEDGNANSEYDVENSMATFATGAQSLMDDGPVGPGSRKPASPYDLHIMTEPYGVPSMVEIFHFLCSLLNVVEHVGMGSRSNTIAFDEDVPLFALNLINSAIELGGSSIRHHPRLLSLIQDELFRNLMQFGLSMSPLILSMVCSIVLNLYQHLRTELKLQLEAFFSCVILRLAQGKYGPSYQQQEVAMEALVNFCRQKSFMVEMYANLDCDITCSNVFEELSNLLSKSTFPVNCPLSAMHILALDGLIAVIQGMAERISNGLTGLDLGPVHLDEYTPFWMVKCDNYSDPNHWVSFVRRRKYIKRRLMIGADHFNRDPKKGLEFLQGTHLLPDKLDPQSVACFFRYTAGLDKNLVGDFLGNHDEFCVQVLNEFAGTFDFQYMNLDTALRLFLETFRLPGESQKIQRVLEAFSERYYMQSPEILANKDAALVLSYSIIMLNTDQHNVQVKKKMTEEDFIRNNRHINGGNDLPREFLSELFHSICNNEIRTTPEQGAGFPEMTPSRWIDLMHKSKKTAPYILADSRAYLDHDMFAIMSGPTIAAISVVFDHAEHEDVYQTCIDGFLAIAKISACHHLEDVLDDLVVSLCKFTTLLNPSSVDEPVLAFGDDAKARMATITIFTIANKYGDYIRTGWRNILDCILRLHKLGLLPARVASDAADESEHSSEQGQGKPLANSLSSAHLQSMGTPRRSSGLMGRFSQLLSLDTEEPRSQPTEQQLAAHQRTLQTIQKCHIDSIFTESKFLQAESLLQLARALIWAAGRPQKGTSSPEDEDTAVFCLELLIAITLNNRDRIVLLWQGVYEHIATIAQSTVMPCNLVDKAIFGLLRICQRLLPYKESLADELLRSLQLVLKLDARVADAYCEQIAIEVSRLVKANANHIRSQAGWRTITSLLSITARHPEASESGFDAVSFVMSEGTHLYPANYVLCVDAARQFAESRVGQSERSIRALDLMGDSLEFLAKWALSAKENMGEEDFGKMSQDIGEMWLRLVQGLRKVCLDQREDVRNHALQSLQKCLGGVDGINLAHSMWSQCFDKVIFTVLDDLLEIAAGSQKDYRNMEGTLLLAIKLLSKVFLQQLQELSQLSTFCKLWLGVLTRMEKYMKVKVRGKKSDKLQESVPELLKNILLVMKTKGVLLQRSALGGDSLWELTWLHVNNIAPSMRLELFPDQESSQLGDDETVSNGLSSPENTTGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
242	Phosphorylation	TLVNRAGSIKQEKAG CCHHCCCCCCHHHCC		23776212
936	Phosphorylation	KPLANSLSSAHLQSM CCCHHHHHHHHHHHC		29654922
937	Phosphorylation	PLANSLSSAHLQSMG CCHHHHHHHHHHHCC		29654922
945	Phosphorylation	AHLQSMGTPRRSSGL HHHHHCCCCCCCCCC		29654922
957	Phosphorylation	SGLMGRFSQLLSLDT CCCHHHHHHHHCCCC		30407730
961	Phosphorylation	GRFSQLLSLDTEEPR HHHHHHHCCCCCCCC		30407730
964	Phosphorylation	SQLLSLDTEEPRSQP HHHHCCCCCCCCCCC		30407730
1437	Phosphorylation	SQLGDDETVSNGLSS HCCCCCCCHHCCCCC		23776212
1439	Phosphorylation	LGDDETVSNGLSSPE CCCCCCHHCCCCCCC		23776212
1443	Phosphorylation	ETVSNGLSSPENTTG CCHHCCCCCCCCCCC		23776212
1444	Phosphorylation	TVSNGLSSPENTTGS CHHCCCCCCCCCCCC		23776212
1448	Phosphorylation	GLSSPENTTGS---- CCCCCCCCCCC----		23776212
1449	Phosphorylation	LSSPENTTGS----- CCCCCCCCCC-----		23776212
1451	Phosphorylation	SPENTTGS------- CCCCCCCC-------		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNOM_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNOM_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNOM_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNOM_ARATH	GN	physical	18203920
GNOM_ARATH	GN	physical	10715321
CP19D_ARATH	CYP5	physical	10715321

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.