GMPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMPR1_HUMAN
• UniProt AC: P36959
• Protein Name: GMP reductase 1 {ECO:0000255|HAMAP-Rule:MF_03195}
• Gene Name: GMPR
• Organism: Homo sapiens (Human).
• Sequence Length: 345
• Protein Description: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides..
• Protein Sequence: MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Malonylation	ADLKLDFKDVLLRPK CCCCCCHHHHHHCCC	46.74	26320211
13	Ubiquitination	ADLKLDFKDVLLRPK CCCCCCHHHHHHCCC	46.74	29967540
13	Acetylation	ADLKLDFKDVLLRPK CCCCCCHHHHHHCCC	46.74	25953088
20	Ubiquitination	KDVLLRPKRSSLKSR HHHHHCCCCCCCCCC	59.48	-
37	Phosphorylation	VDLERTFTFRNSKQT ECCEEEEEECCCCCE	22.52	-
81	Phosphorylation	TAIHKHYSLDDWKLF HHHHCCCCCCHHHHE	25.66	-
267	Phosphorylation	GRKLKLFYGMSSDTA CCEEEEEEECCCHHH	23.50	22817900
270	Phosphorylation	LKLFYGMSSDTAMNK EEEEEECCCHHHHHH	22.24	27251275
271	Phosphorylation	KLFYGMSSDTAMNKH EEEEECCCHHHHHHH	30.04	27251275
273	Phosphorylation	FYGMSSDTAMNKHAG EEECCCHHHHHHHCC	29.74	27251275
314	Phosphorylation	DILGGLRSTCTYVGA HHHHHHHHHCCHHCH	32.64	21406692
315	Phosphorylation	ILGGLRSTCTYVGAA HHHHHHHHCCHHCHH	11.48	21406692
317	Phosphorylation	GGLRSTCTYVGAAKL HHHHHHCCHHCHHHH	22.72	21406692
318	Phosphorylation	GLRSTCTYVGAAKLK HHHHHCCHHCHHHHH	10.07	28152594
318	Nitration	GLRSTCTYVGAAKLK HHHHHCCHHCHHHHH	10.07	-
323	Acetylation	CTYVGAAKLKELSRR CCHHCHHHHHHHHHH	60.60	25953088
332	Phosphorylation	KELSRRATFIRVTQQ HHHHHHCCEEEEHHH	20.13	23186163
345	Phosphorylation	QQHNTVFS------- HHCCCCCC-------	34.67	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GMPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMPR1_HUMAN	GMPR	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.