dbPTM

GMD2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GMD2_ARATH
UniProt AC	P93031
Protein Name	GDP-mannose 4,6 dehydratase 2
Gene Name	MUR1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	373
Subcellular Localization
Protein Description	Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose..
Protein Sequence	MASENNGSRSDSESITAPKADSTVVEPRKIALITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQRINHIYIDPHNVNKALMKLHYADLTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRSHTIDSGRTVKYYQAGSSEMFGSTPPPQSETTPFHPRSPYAASKCAAHWYTVNYREAYGLFACNGILFNHESPRRGENFVTRKITRALGRIKVGLQTKLFLGNLQASRDWGFAGDYVEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKDYVEIDQRYFRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVKMMVDEDLELAKREKVLVDAGYMDAKQQP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASENNGSRS -----CCCCCCCCCC	39.29	27532006
8	Phosphorylation	MASENNGSRSDSESI CCCCCCCCCCCCCCC	30.63	30407730
10	Phosphorylation	SENNGSRSDSESITA CCCCCCCCCCCCCCC	47.38	27532006
12	Phosphorylation	NNGSRSDSESITAPK CCCCCCCCCCCCCCC	34.19	23776212
14	Phosphorylation	GSRSDSESITAPKAD CCCCCCCCCCCCCCC	29.23	23776212
16	Phosphorylation	RSDSESITAPKADST CCCCCCCCCCCCCCC	46.30	19376835
22	Phosphorylation	ITAPKADSTVVEPRK CCCCCCCCCCCCCCE	28.14	19880383
23	Phosphorylation	TAPKADSTVVEPRKI CCCCCCCCCCCCCEE	29.17	22631563
367	Sulfoxidation	VLVDAGYMDAKQQP- EEEECCCCCCCCCC-	3.85	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GMD2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GMD2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GMD2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FCL1_ARATH	GER1	physical	12881408

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GMD2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	19376835 [Abstract]