GLSL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLSL_HUMAN
• UniProt AC: Q9UI32
• Protein Name: Glutaminase liver isoform, mitochondrial
• Gene Name: GLS2
• Organism: Homo sapiens (Human).
• Sequence Length: 602
• Subcellular Localization: Mitochondrion .
• Protein Description: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation..
• Protein Sequence: MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	MHRVVQESSSGGLLD HHHHHHHCCCCCCCC	16.83	22210691
136	S-nitrosylation	DRDLFRKCVSSNIVL CHHHHHHHHHCCHHH	2.90	24105792
138	Phosphorylation	DLFRKCVSSNIVLLT HHHHHHHHCCHHHHC	27.43	30576142
139	Phosphorylation	LFRKCVSSNIVLLTQ HHHHHHHCCHHHHCH	15.35	30576142
145	Phosphorylation	SSNIVLLTQAFRKKF HCCHHHHCHHHHHCC	17.43	30576142
253	Succinylation	PSGLRYNKLSLNEEG CCCCCCCCCCCCCCC	30.44	-
253	Succinylation	PSGLRYNKLSLNEEG CCCCCCCCCCCCCCC	30.44	-
276	Phosphorylation	AGAIVVSSLIKMDCN HHHEEEECHHHCCCC	23.62	24719451
279	Acetylation	IVVSSLIKMDCNKAE EEEECHHHCCCCHHH	33.70	-
284	Acetylation	LIKMDCNKAEKFDFV HHHCCCCHHHHHHHH	65.34	-
303	Phosphorylation	NKMAGNEYMGFSNAT HHHCCCCCCCCCCCE	13.41	-
310	Phosphorylation	YMGFSNATFQSEKET CCCCCCCEEECCHHH	26.85	-
317	Phosphorylation	TFQSEKETGDRNYAI EEECCHHHCCCCEEH	56.29	25072903
322	Phosphorylation	KETGDRNYAIGYYLK HHHCCCCEEHHHHHC	10.65	25072903
326	Phosphorylation	DRNYAIGYYLKEKKC CCCEEHHHHHCCCCC	10.26	26434776
327	Phosphorylation	RNYAIGYYLKEKKCF CCEEHHHHHCCCCCC	13.19	26434776
329	Acetylation	YAIGYYLKEKKCFPK EEHHHHHCCCCCCCC	51.90	-
485	Ubiquitination	EGAEIRNKTVVNLLF CCCHHCCHHHHHHHH	32.61	-
486	Phosphorylation	GAEIRNKTVVNLLFA CCHHCCHHHHHHHHH	32.98	22210691
495	Phosphorylation	VNLLFAAYSGDVSAL HHHHHHHHCCCHHHH	15.12	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLSL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLSL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
310	Phosphorylation	316 (6)	L ⇒ P	rs2657879	Metabolic traits Blood metabolite levels Amino acid levels Metabolite levels (small molecules and protein measures)	21886157 24816252 26068415 27005778

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRHPR_HUMAN	GRHPR	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.