GLR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLR_HUMAN
• UniProt AC: P47871
• Protein Name: Glucagon receptor
• Gene Name: GCGR
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding.
• Protein Description: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system..
• Protein Sequence: MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	ACQPQVPSAQVMDFL HCCCCCCCHHHHHHH	32.26	-
46	N-linked_Glycosylation	YGDQCHHNLSLLPPP CCCCCCCCCCCCCCC	13.99	28514451
59	N-linked_Glycosylation	PPTELVCNRTFDKYS CCCEEEECCCCCCCC	38.25	28514451
74	N-linked_Glycosylation	CWPDTPANTTANISC CCCCCCCCCCCCEEC	38.88	22908259
78	N-linked_Glycosylation	TPANTTANISCPWYL CCCCCCCCEECCCCC	25.31	22908259
437	Phosphorylation	TSNHRASSSPGHGPP CCCCCCCCCCCCCCC	39.30	21902226
438	Phosphorylation	SNHRASSSPGHGPPS CCCCCCCCCCCCCCC	32.19	-
445	Phosphorylation	SPGHGPPSKELQFGR CCCCCCCCCCCCCCC	41.73	-
456	Phosphorylation	QFGRGGGSQDSSAET CCCCCCCCCCCCCCC	33.80	20166139
459	Phosphorylation	RGGGSQDSSAETPLA CCCCCCCCCCCCCCC	24.66	22908259
460	Phosphorylation	GGGSQDSSAETPLAG CCCCCCCCCCCCCCC	38.11	25072903
463	Phosphorylation	SQDSSAETPLAGGLP CCCCCCCCCCCCCCC	24.26	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGM2_HUMAN	TGM2	physical	21988832
P63_HUMAN	TP63	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00116: Glucagon (JAN/USP/INN); Glucagon (genetical recombination) (JAN); Glucagon (TN)
• D02118: Glucagon hydrochloride; Glucagon monohydrochloride; Glucagon (TN)
• DrugBank
• There are no disease associations of PTM sites.