GLNA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLNA2_ARATH
• UniProt AC: Q43127
• Protein Name: Glutamine synthetase, chloroplastic/mitochondrial
• Gene Name: GLN2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 430
• Subcellular Localization: Plastid, chloroplast . Mitochondrion .
• Protein Description: The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration..
• Protein Sequence: MAQILAASPTCQMRVPKHSSVIASSSKLWSSVVLKQKKQSNNKVRGFRVLALQSDNSTVNRVETLLNLDTKPYSDRIIAEYIWIGGSGIDLRSKSRTIEKPVEDPSELPKWNYDGSSTGQAPGEDSEVILYPQAIFRDPFRGGNNILVICDTWTPAGEPIPTNKRAKAAEIFSNKKVSGEVPWFGIEQEYTLLQQNVKWPLGWPVGAFPGPQGPYYCGVGADKIWGRDISDAHYKACLYAGINISGTNGEVMPGQWEFQVGPSVGIDAGDHVWCARYLLERITEQAGVVLTLDPKPIEGDWNGAGCHTNYSTKSMREEGGFEVIKKAILNLSLRHKEHISAYGEGNERRLTGKHETASIDQFSWGVANRGCSIRVGRDTEAKGKGYLEDRRPASNMDPYIVTSLLAETTLLWEPTLEAEALAAQKLSLNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	FRVLALQSDNSTVNR EEEEEEECCCCHHHH	39.34	29654922
74	Phosphorylation	NLDTKPYSDRIIAEY CCCCCCCCCCEEEEE	29.01	30291188
93	Phosphorylation	GSGIDLRSKSRTIEK CCCCCCCCCCCEECC	42.13	23172892
95	Phosphorylation	GIDLRSKSRTIEKPV CCCCCCCCCEECCCC	35.58	23172892
97	Phosphorylation	DLRSKSRTIEKPVED CCCCCCCEECCCCCC	40.35	27545962
106	Phosphorylation	EKPVEDPSELPKWNY CCCCCCHHHCCCCCC	65.18	30291188
173	Phosphorylation	AKAAEIFSNKKVSGE HHHHHHHCCCCCCCC	54.09	25561503
178	Phosphorylation	IFSNKKVSGEVPWFG HHCCCCCCCCCCCCC	37.81	26811356
223	Acetylation	YCGVGADKIWGRDIS CCCCCCCCCCCCCCC	39.56	21311031
314	Phosphorylation	HTNYSTKSMREEGGF CCCCCCCHHHHHCCH	24.14	25561503
315	Sulfoxidation	TNYSTKSMREEGGFE CCCCCCHHHHHCCHH	7.15	25693801
332	Phosphorylation	KKAILNLSLRHKEHI HHHHHHHHHCCHHHH	23.45	25561503
340	Phosphorylation	LRHKEHISAYGEGNE HCCHHHHHCCCCCCC	19.83	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLNA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLNA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLNA2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO3_ARATH	SUMO3	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.
PubMed: 19376835