GGACT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGACT_HUMAN
• UniProt AC: Q9BVM4
• Protein Name: Gamma-glutamylaminecyclotransferase
• Gene Name: GGACT
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Protein Description: Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine..
• Protein Sequence: MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MALVFVYGTLKRGQ -CCEEEEEEEECCCC		24043423
9	Phosphorylation	ALVFVYGTLKRGQPN CEEEEEEEECCCCCC		24043423
147	Phosphorylation	EGPHGLRYNPRENR- CCCCCCCCCCCCCC-		20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGACT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGACT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGACT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HRSL5_HUMAN	HRASLS5	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.