GFRA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GFRA2_HUMAN
• UniProt AC: O00451
• Protein Name: GDNF family receptor alpha-2
• Gene Name: GFRA2
• Organism: Homo sapiens (Human).
• Sequence Length: 464
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3..
• Protein Sequence: MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	ELCAAESNCSSRYRT HHHHHHCCHHHHHHH	22.61	UniProtKB CARBOHYD
71	Phosphorylation	LAGRDRNTMLANKEC HHCCCHHHHHCCHHH	17.92	30242111
179	Phosphorylation	DNCKKLRSSYISICN HHHHHHHHHHHHHHC	37.62	-
357	N-linked_Glycosylation	NAIQAFGNGTDVNVS HHHHHHCCCCCCCCC	43.68	UniProtKB CARBOHYD
369	Phosphorylation	NVSPKGPSFQATQAP CCCCCCCCCCCCCCC	38.36	22985185
396	O-linked_Glycosylation	SDSTSLGTSVITTCT CCCCCCCCHHHHCCH	25.72	OGP
401	O-linked_Glycosylation	LGTSVITTCTSVQEQ CCCHHHHCCHHHHHH	11.58	OGP
413	N-linked_Glycosylation	QEQGLKANNSKELSM HHHCCCCCCCHHHHH	52.28	UniProtKB CARBOHYD
441	Phosphorylation	NKVIKPNSGPSRARP CCCCCCCCCCCCCCH	61.68	-
444	Phosphorylation	IKPNSGPSRARPSAA CCCCCCCCCCCHHHH	41.94	-
444	GPI-anchor	IKPNSGPSRARPSAA CCCCCCCCCCCHHHH	41.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GFRA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GFRA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GFRA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRTN_HUMAN	NRTN	physical	9407096
GDNF_HUMAN	GDNF	physical	9407096
NRTN_HUMAN	NRTN	physical	10829012
GDNF_HUMAN	GDNF	physical	10829012

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.