GDF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDF8_HUMAN
• UniProt AC: O14793
• Protein Name: Growth/differentiation factor 8
• Gene Name: MSTN
• Organism: Homo sapiens (Human).
• Sequence Length: 375
• Subcellular Localization: Secreted .
• Protein Description: Acts specifically as a negative regulator of skeletal muscle growth..
• Protein Sequence: MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	AIKIQILSKLRLETA HHHHHHHHHCCCCCC	31.13	24719451
71	N-linked_Glycosylation	LRLETAPNISKDVIR CCCCCCCCCCHHHHH	49.02	UniProtKB CARBOHYD
304	Phosphorylation	WIIAPKRYKANYCSG EEECCCCEECCCCCC	22.15	-
308	Phosphorylation	PKRYKANYCSGECEF CCCEECCCCCCEEEE	7.89	-
310	Phosphorylation	RYKANYCSGECEFVF CEECCCCCCEEEEEE	27.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDF8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDF8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FSTL3_HUMAN	FSTL3	physical	12194980
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.