GBA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBA3_HUMAN
• UniProt AC: Q9H227
• Protein Name: Cytosolic beta-glucosidase
• Gene Name: GBA3
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide..
• Protein Sequence: MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLEAHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	DRVKQWITINEANVL HHHHEEEEECHHHEE	18.13	-
174	Phosphorylation	NVLSVMSYDLGMFPP HEEEEEECCCCCCCC	9.33	-
238	Phosphorylation	PADPNSVSDQEAAKR CCCCCCCCHHHHHHH	33.14	29759185
244	Ubiquitination	VSDQEAAKRAITFHL CCHHHHHHHHHHHHH	49.78	-
290	Phosphorylation	SSRLPEFTEEEKKMI HHHCCCCCHHHHHHH	40.60	22468782
392	Phosphorylation	DDTQRWEYFRQTFQE CCHHHHHHHHHHHHH	9.33	26330541
396	Phosphorylation	RWEYFRQTFQELFKA HHHHHHHHHHHHHHH	24.03	26330541
450	Phosphorylation	PARPRVPYTSAKEYA CCCCCCCCCCHHHHH	15.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLU2B_HUMAN	PRKCSH	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.