GATA6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA6_RAT
• UniProt AC: P46153
• Protein Name: Transcription factor GATA-6
• Gene Name: Gata6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 587
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions..
• Protein Sequence: MALTDGGWCLPKRFGAAAADAGDSGPFPAREPSSPLSPISSSSSSCSRGGDRGPCGASNCRTPQLDTEAVAGPPGRSLLLSPYTSHPFAAAHGAAAPGVAGPGSALSTWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAAEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYLQGAGSGPSNHAGGAGAHPGWPQASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPYSPSPPMANGAARDPGGYVAAGGAGAGSVSGGGGSLAAMGGREHQYSSLSAARPLNGTYHHHHHHHPTYSPYMGAPLTPAWPAGPFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKACSGNSSVPMTPTSSSSNSDDCTKNTSPPTQSTASGVGASVMSAVGESANPENSDLKYSGQDGLYIGVSLSSPAEVTSSVRQDSWCALALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
264	Phosphorylation	ASARFPYSPSPPMAN HHCCCCCCCCCCCCC	21.09	28689409
266	Phosphorylation	ARFPYSPSPPMANGA CCCCCCCCCCCCCCC	35.38	22673903
371	Phosphorylation	LPVPRGPSADLLEDL CCCCCCCCHHHHHHH	36.92	26022182
381	Phosphorylation	LLEDLSESRECVNCG HHHHHHHCCCCCCCC	29.97	26022182
389	Phosphorylation	RECVNCGSIQTPLWR CCCCCCCCCCCCCEE	17.45	26022182
430	Phosphorylation	KPQKRVPSSRRLGLS CCCCCCCCHHCCCCC	33.35	24972320
431	Phosphorylation	PQKRVPSSRRLGLSC CCCCCCCHHCCCCCC	18.49	24972320

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATA6_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA6_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRF_HUMAN	SRF	physical	12530967

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.