GAS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAS2_HUMAN
• UniProt AC: O43903
• Protein Name: Growth arrest-specific protein 2
• Gene Name: GAS2
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyper
• Protein Description: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity)..
• Protein Sequence: MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MCTALSPKVR -----CCCCCCCCCC	29.36	30108239
6	Phosphorylation	--MCTALSPKVRSGP --CCCCCCCCCCCCC	21.88	28188228
11	Phosphorylation	ALSPKVRSGPGLSDM CCCCCCCCCCCCHHH	52.94	29978859
16	Phosphorylation	VRSGPGLSDMHQYSQ CCCCCCCHHHHHHHH	38.51	22210691
21	Phosphorylation	GLSDMHQYSQWLASR CCHHHHHHHHHHHHH	6.53	29978859
22	Phosphorylation	LSDMHQYSQWLASRH CHHHHHHHHHHHHHH	14.33	29978859
27	Phosphorylation	QYSQWLASRHEANLL HHHHHHHHHHHHHCC	31.81	29978859
53	Phosphorylation	NLLGKEITAETFMEK HHHCCCCCHHHHHHH	21.38	29691806
56	Phosphorylation	GKEITAETFMEKLDN CCCCCHHHHHHHCCH	26.31	29691806
86	Ubiquitination	KESMDANKPTKNLPL HHHHHCCCCCCCCCC	56.64	-
100	Phosphorylation	LKKIPCKTSAPSGSF CCCCCCCCCCCCCCC	36.52	-
101	Phosphorylation	KKIPCKTSAPSGSFF CCCCCCCCCCCCCCC	24.55	-
104	Phosphorylation	PCKTSAPSGSFFARD CCCCCCCCCCCCCCC	46.95	-
106	Phosphorylation	KTSAPSGSFFARDNT CCCCCCCCCCCCCCC	22.87	-
178	Phosphorylation	KEIEQEETLSAPSPS CHHCCCCCCCCCCCC	25.84	30108239
180	Phosphorylation	IEQEETLSAPSPSPS HCCCCCCCCCCCCCC	45.62	30108239
183	Phosphorylation	EETLSAPSPSPSPSS CCCCCCCCCCCCCCC	37.41	26657352
185	Phosphorylation	TLSAPSPSPSPSSKS CCCCCCCCCCCCCCC	42.20	26657352
187	Phosphorylation	SAPSPSPSPSSKSSG CCCCCCCCCCCCCCC	41.57	30576142
189	Phosphorylation	PSPSPSPSSKSSGKK CCCCCCCCCCCCCCC	55.52	30576142
190	Phosphorylation	SPSPSPSSKSSGKKS CCCCCCCCCCCCCCC	39.68	30108239
197	Phosphorylation	SKSSGKKSTGNLLDD CCCCCCCCCCCHHHH	45.06	24275569
227	Phosphorylation	KFCVERLSQGRYRVG CHHHHHHHCCCCCCC	36.49	29449344
231	Phosphorylation	ERLSQGRYRVGEKIL HHHHCCCCCCCCEEE	19.24	29449344
258	Phosphorylation	RVGGGWETFAGYLLK EECCCHHHHHHHHHH	16.57	-
262	Phosphorylation	GWETFAGYLLKHDPC CHHHHHHHHHHCCCC	12.87	-
281	Phosphorylation	ISRVDGKTSPIQSKS EEEECCCCCCCCCCC	45.31	28258704
282	Phosphorylation	SRVDGKTSPIQSKSP EEECCCCCCCCCCCC	24.40	22617229
286	Phosphorylation	GKTSPIQSKSPTLKD CCCCCCCCCCCCCCC	35.50	30108239
288	Phosphorylation	TSPIQSKSPTLKDMN CCCCCCCCCCCCCCC	28.50	20166139
290	Phosphorylation	PIQSKSPTLKDMNPD CCCCCCCCCCCCCCC	54.23	28857561
299	Phosphorylation	KDMNPDNYLVVSASY CCCCCCCEEEEEEEH	14.30	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.