GAPN_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAPN_ARATH
• UniProt AC: Q1WIQ6
• Protein Name: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
• Gene Name: ALDH11A3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 496
• Subcellular Localization: Cytoplasm.
• Protein Description: Important as a means of generating NADPH for biosynthetic reactions..
• Protein Sequence: MAGTGLFAEILDGEVYKYYADGEWKTSSSGKSVAIMNPATRKTQYKVQACTQEEVNAVMELAKSAQKSWAKTPLWKRAELLHKAAAILKDNKAPMAESLVKEIAKPAKDSVTEVVRSGDLISYCAEEGVRILGEGKFLLSDSFPGNDRTKYCLTSKIPLGVVLAIPPFNYPVNLAVSKIAPALIAGNSLVLKPPTQGAVSCLHMVHCFHLAGFPKGLISCITGKGSEIGDFLTMHPAVNCISFTGGDTGISISKKAGMIPLQMELGGKDACIVLDDADLDLVASNIIKGGFSYSGQRCTAVKVVLVMESVADELVEKVKAKVAKLTVGPPEENSDITAVVSESSANFIEGLVMDAKEKGATFCQEYKREGNLIWPLLLDNVRPDMRIAWEEPFGPVVPVLRINSVEEGINHCNASNFGLQGCVFTKDINKAILISDAMETGTVQINSAPARGPDHFPFQGLKDSGIGSQGVTNSINLMTKVKTTVINLPTPSYSMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGTGLFAE ------CCCCCCEEE	25.01	22223895
4	Phosphorylation	----MAGTGLFAEIL ----CCCCCCEEEHH	22.60	19376835
98	Phosphorylation	NKAPMAESLVKEIAK CCCCHHHHHHHHHHH	28.99	19880383
142	Phosphorylation	GKFLLSDSFPGNDRT CCEEECCCCCCCCCC	29.93	30291188
490	Phosphorylation	TTVINLPTPSYSMG- EEEEECCCCCCCCC-	28.21	25561503
492	Phosphorylation	VINLPTPSYSMG--- EEECCCCCCCCC---	32.11	25561503
493	Phosphorylation	INLPTPSYSMG---- EECCCCCCCCC----	12.13	25561503
494	Phosphorylation	NLPTPSYSMG----- ECCCCCCCCC-----	22.74	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAPN_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAPN_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAPN_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAPN_ARATH	ALDH11A3	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4, AND MASSSPECTROMETRY.
PubMed: 19376835