GABR2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABR2_RAT
• UniProt AC: O88871
• Protein Name: Gamma-aminobutyric acid type B receptor subunit 2
• Gene Name: Gabbr2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 940
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transpor
• Protein Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. [PubMed: 9872315]
• Protein Sequence: MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	N-linked_Glycosylation	LAIEQIRNESLLRPY HHHHHHHCCCCCCCC	44.85	-
297	N-linked_Glycosylation	EQVHVEANSSRCLRR EEEEHHHHCHHHHHH	27.32	-
388	N-linked_Glycosylation	HQRIQDFNYTDHTLG HHHHHHCCCCCHHHH	47.27	24090084
403	N-linked_Glycosylation	KIILNAMNETNFFGV HHHHHHHCCCCCCCC	51.00	-
452	N-linked_Glycosylation	ADTLEIINDTIRFQG HHHHHHHHHCHHCCC	46.14	-
754	Phosphorylation	RTNPDAATQNRRFQF CCCCCHHHCCHHEEE	28.26	25403869
762	Phosphorylation	QNRRFQFTQNQKKED CCHHEEECCCCCCCC	18.81	27097102
770	Phosphorylation	QNQKKEDSKTSTSVT CCCCCCCCCCCCCCE	38.64	25403869
771	Ubiquitination	NQKKEDSKTSTSVTS CCCCCCCCCCCCCEE	59.84	-
772	Phosphorylation	QKKEDSKTSTSVTSV CCCCCCCCCCCCEEC	40.98	25403869
773	Phosphorylation	KKEDSKTSTSVTSVN CCCCCCCCCCCEECH	23.56	30240740
774	Phosphorylation	KEDSKTSTSVTSVNQ CCCCCCCCCCEECHH	32.23	25403869
775	Phosphorylation	EDSKTSTSVTSVNQA CCCCCCCCCEECHHH	24.14	30240740
777	Phosphorylation	SKTSTSVTSVNQAST CCCCCCCEECHHHCH	27.07	25403869
778	Phosphorylation	KTSTSVTSVNQASTS CCCCCCEECHHHCHH	19.54	30240740
783	Phosphorylation	VTSVNQASTSRLEGL CEECHHHCHHHHHHH	19.70	20643948
792	Phosphorylation	SRLEGLQSENHRLRM HHHHHHHCCCHHHHH	45.46	25403869
800	Ubiquitination	ENHRLRMKITELDKD CCHHHHHHHHHHHCC	39.79	-
818	Phosphorylation	VTMQLQDTPEKTTYI HHHHHCCCCCHHCCC	22.01	30240740
824	Phosphorylation	DTPEKTTYIKQNHYQ CCCCHHCCCCCCCHH	16.02	-
873	Phosphorylation	NTTEPSRTCKDPIED CCCCCCCCCCCCCHH	28.39	28551015
883	Phosphorylation	DPIEDINSPEHIQRR CCCHHCCCHHHHHHH	31.81	30411139
892	Phosphorylation	EHIQRRLSLQLPILH HHHHHHHHCCCCCCC	16.56	14707142
912	Phosphorylation	SIGGVDASCVSPCVS CCCCCCHHHCCCCCC	15.58	-
915	Phosphorylation	GVDASCVSPCVSPTA CCCHHHCCCCCCCCC	19.53	-
919	Phosphorylation	SCVSPCVSPTASPRH HHCCCCCCCCCCCCC	24.21	-
923	Phosphorylation	PCVSPTASPRHRHVP CCCCCCCCCCCCCCC	25.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
783	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
892	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABR2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABR2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	24114844
PRS8_HUMAN	PSMC5	physical	24482233
PRS8_RAT	Psmc5	physical	24482233

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.