GABR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABR1_RAT
• UniProt AC: Q9Z0U4
• Protein Name: Gamma-aminobutyric acid type B receptor subunit 1
• Gene Name: Gabbr1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 991
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Perikaryon . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transpor
• Protein Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. [PubMed: 9872315]
• Protein Sequence: MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	N-linked_Glycosylation	AGGAQTPNATSEGCQ CCCCCCCCCCCCCCC	60.27	-
83	N-linked_Glycosylation	KVRKCLANGSWTDMD HHHHHHHCCCCCCCC	31.89	24090084
227	Phosphorylation	DPGQATKYLYELLYN CHHHHHHHHHHHHHC	15.34	25575281
229	Phosphorylation	GQATKYLYELLYNDP HHHHHHHHHHHHCCC	11.05	25575281
233	Phosphorylation	KYLYELLYNDPIKII HHHHHHHHCCCEEEE	30.09	25575281
246	Phosphorylation	IILMPGCSSVSTLVA EEEECCCCHHHHHHH	39.42	25575281
247	Phosphorylation	ILMPGCSSVSTLVAE EEECCCCHHHHHHHH	24.94	25575281
249	Phosphorylation	MPGCSSVSTLVAEAA ECCCCHHHHHHHHHH	20.26	25575281
250	Phosphorylation	PGCSSVSTLVAEAAR CCCCHHHHHHHHHHH	24.09	25575281
408	N-linked_Glycosylation	KTYDPSINCTVEEMT HHCCCCCCCCHHHHH	21.53	-
439	N-linked_Glycosylation	ANTRSISNMTSQEFV CCCCCCCCCCHHHHH	35.76	24090084
481	N-linked_Glycosylation	WALALALNKTSGGGG HHHHHHHHCCCCCCC	39.70	-
501	N-linked_Glycosylation	LEDFNYNNQTITDQI HHHCCCCCCCHHHHH	29.97	-
513	N-linked_Glycosylation	DQIYRAMNSSSFEGV HHHHHHHHCCCCCCC	37.44	-
903	Phosphorylation	WQSETQDTMKTGSST CCCCCCCCCCCCCCC	15.68	-
906	Phosphorylation	ETQDTMKTGSSTNNN CCCCCCCCCCCCCCC	31.32	28551015
908	Phosphorylation	QDTMKTGSSTNNNEE CCCCCCCCCCCCCHH	38.94	28551015
909	Phosphorylation	DTMKTGSSTNNNEEE CCCCCCCCCCCCHHH	36.18	21373199
910	Phosphorylation	TMKTGSSTNNNEEEK CCCCCCCCCCCHHHH	43.60	28551015
917	Ubiquitination	TNNNEEEKSRLLEKE CCCCHHHHHHHHHHH	44.12	-
923	Ubiquitination	EKSRLLEKENRELEK HHHHHHHHHHHHHHH	61.33	-
935	Acetylation	LEKIIAEKEERVSEL HHHHHHHHHHHHHHH	56.72	72601015
935	Ubiquitination	LEKIIAEKEERVSEL HHHHHHHHHHHHHHH	56.72	-
948	Phosphorylation	ELRHQLQSRQQLRSR HHHHHHHHHHHHHHC	40.42	17224405
960	Phosphorylation	RSRRHPPTPPDPSGG HHCCCCCCCCCCCCC	52.48	30240740
965	Phosphorylation	PPTPPDPSGGLPRGP CCCCCCCCCCCCCCC	53.53	30240740
980	Phosphorylation	SEPPDRLSCDGSRVH CCCCCCCCCCCCEEE	15.85	25403869
984	Phosphorylation	DRLSCDGSRVHLLYK CCCCCCCCEEEEEEC	20.20	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
898	S	Phosphorylation	Kinase	CAMK2B	Q13554	PSP
948	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABR1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	24114844
GABR2_RAT	Gabbr2	physical	24114844

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.