dbPTM

GAB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GAB1_MOUSE
UniProt AC	Q9QYY0
Protein Name	GRB2-associated-binding protein 1
Gene Name	Gab1
Organism	Mus musculus (Mouse).
Sequence Length	695
Subcellular Localization
Protein Description	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity)..
Protein Sequence	MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVKPLTGSSQAPVDSPFAISTAPASSQMEASSVALPPPYQVISLPPHPDTLGLQDDPQDYLLLINCQSKKPEPNRTLFDSAKPTFSETDCNDNVPSHQTPASSQSKHGMNGFFQQQMMYDCPPSRLTSVSGESSLYNLPRSYSHDVLPKESPSSTEADGELYTFNTPSGTAGVETQMRHVSISYDIPPTPGNTYQIPRTFPESTLGQSSKLDTIPDIPPPRPPKPHPTHDRSPVETCGVPRTASDTDSSYCIPPPAGMTPSRSNTISTVDLNKLRKDASSQDCYDIPRTFPSDRSSSLEGFHSQYKIKSVLTAGGVSGEELDENYVPMNPNSPPRQHSGSFTEPIQEPNYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLDIKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSGEDPNLFASNSLDGGSSPMNKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSMADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKNVK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGGEVVCS ------CCCCEEEEC	56.35	-
15	Phosphorylation	CSGWLRKSPPEKKLK ECCCCCCCCCHHHHH	38.97	28059163
83	Phosphorylation	KKEFENSYIFDINTI HHHHCCCEEEECCCC	19.72	-
205	Ubiquitination	RTLFDSAKPTFSETD CCCCCCCCCCCCCCC	48.84	-
242	Phosphorylation	FFQQQMMYDCPPSRL CCCHHHCCCCCHHHC	14.73	22817900
250	Phosphorylation	DCPPSRLTSVSGESS CCCHHHCEEECCCHH	26.44	22499769
251	Phosphorylation	CPPSRLTSVSGESSL CCHHHCEEECCCHHH	20.91	26824392
253	Phosphorylation	PSRLTSVSGESSLYN HHHCEEECCCHHHHC	36.29	26239621
256	Phosphorylation	LTSVSGESSLYNLPR CEEECCCHHHHCCCC	29.21	22499769
257	Phosphorylation	TSVSGESSLYNLPRS EEECCCHHHHCCCCC	30.48	22499769
259	Phosphorylation	VSGESSLYNLPRSYS ECCCHHHHCCCCCCC	19.32	18515860
264	Phosphorylation	SLYNLPRSYSHDVLP HHHCCCCCCCCCCCC	29.10	25521595
265	Phosphorylation	LYNLPRSYSHDVLPK HHCCCCCCCCCCCCC	16.00	25777480
266	Phosphorylation	YNLPRSYSHDVLPKE HCCCCCCCCCCCCCC	17.92	25521595
274	Phosphorylation	HDVLPKESPSSTEAD CCCCCCCCCCCCCCC	35.89	25338131
276	Phosphorylation	VLPKESPSSTEADGE CCCCCCCCCCCCCCC	60.20	25338131
277	Phosphorylation	LPKESPSSTEADGEL CCCCCCCCCCCCCCE	33.38	25338131
278	Phosphorylation	PKESPSSTEADGELY CCCCCCCCCCCCCEE	39.26	29899451
285	Phosphorylation	TEADGELYTFNTPSG CCCCCCEEEEECCCC	12.65	10734310
304	Phosphorylation	ETQMRHVSISYDIPP CEEEEEEEEEEECCC	10.33	19060867
306	Phosphorylation	QMRHVSISYDIPPTP EEEEEEEEEECCCCC	14.83	21183079
307	Phosphorylation	MRHVSISYDIPPTPG EEEEEEEEECCCCCC	19.07	10734310
312	Phosphorylation	ISYDIPPTPGNTYQI EEEECCCCCCCCEEC	38.17	23684622
316	Phosphorylation	IPPTPGNTYQIPRTF CCCCCCCCEECCCCC	23.79	26026062
317	Phosphorylation	PPTPGNTYQIPRTFP CCCCCCCEECCCCCC	14.40	22817900
322	Phosphorylation	NTYQIPRTFPESTLG CCEECCCCCCCCCCC	37.88	26643407
322	O-linked_Glycosylation	NTYQIPRTFPESTLG CCEECCCCCCCCCCC	37.88	55412073
326	Phosphorylation	IPRTFPESTLGQSSK CCCCCCCCCCCCCCC	29.21	26643407
327	Phosphorylation	PRTFPESTLGQSSKL CCCCCCCCCCCCCCC	32.99	26643407
331	Phosphorylation	PESTLGQSSKLDTIP CCCCCCCCCCCCCCC	27.87	24719451
332	Phosphorylation	ESTLGQSSKLDTIPD CCCCCCCCCCCCCCC	29.38	26643407
336	Phosphorylation	GQSSKLDTIPDIPPP CCCCCCCCCCCCCCC	44.86	26060331
351	Phosphorylation	RPPKPHPTHDRSPVE CCCCCCCCCCCCCCC	33.12	26060331
355	Phosphorylation	PHPTHDRSPVETCGV CCCCCCCCCCCCCCC	39.08	26824392
365	Phosphorylation	ETCGVPRTASDTDSS CCCCCCCCCCCCCCC	25.17	23527152
367	Phosphorylation	CGVPRTASDTDSSYC CCCCCCCCCCCCCCC	40.19	26643407
369	Phosphorylation	VPRTASDTDSSYCIP CCCCCCCCCCCCCCC	34.97	26643407
371	Phosphorylation	RTASDTDSSYCIPPP CCCCCCCCCCCCCCC	25.87	26643407
372	Phosphorylation	TASDTDSSYCIPPPA CCCCCCCCCCCCCCC	27.17	26643407
373	Phosphorylation	ASDTDSSYCIPPPAG CCCCCCCCCCCCCCC	9.80	10734310
382	Phosphorylation	IPPPAGMTPSRSNTI CCCCCCCCCCCCCEE	19.73	23527152
386	Phosphorylation	AGMTPSRSNTISTVD CCCCCCCCCEEEEEE	42.54	19060867
388	Phosphorylation	MTPSRSNTISTVDLN CCCCCCCEEEEEEHH	19.97	25521595
390	Phosphorylation	PSRSNTISTVDLNKL CCCCCEEEEEEHHHH	21.97	25521595
391	Phosphorylation	SRSNTISTVDLNKLR CCCCEEEEEEHHHHC	17.75	25521595
402	Phosphorylation	NKLRKDASSQDCYDI HHHCCCCCCCCCCCC	38.37	25619855
403	Phosphorylation	KLRKDASSQDCYDIP HHCCCCCCCCCCCCC	31.58	25619855
407	Phosphorylation	DASSQDCYDIPRTFP CCCCCCCCCCCCCCC	25.79	10734310
412	Phosphorylation	DCYDIPRTFPSDRSS CCCCCCCCCCCCCCH	34.25	23684622
415	Phosphorylation	DIPRTFPSDRSSSLE CCCCCCCCCCCHHCC	41.27	26643407
418	Phosphorylation	RTFPSDRSSSLEGFH CCCCCCCCHHCCCHH	29.30	27742792
419	Phosphorylation	TFPSDRSSSLEGFHS CCCCCCCHHCCCHHH	39.58	27742792
420	Phosphorylation	FPSDRSSSLEGFHSQ CCCCCCHHCCCHHHH	31.52	26824392
426	Phosphorylation	SSLEGFHSQYKIKSV HHCCCHHHHHEECEE	32.70	18846507
428	Phosphorylation	LEGFHSQYKIKSVLT CCCHHHHHEECEEEE	20.07	26643407
432	Phosphorylation	HSQYKIKSVLTAGGV HHHHEECEEEECCCC	26.32	26643407
435	Phosphorylation	YKIKSVLTAGGVSGE HEECEEEECCCCCHH	22.54	26643407
440	Phosphorylation	VLTAGGVSGEELDEN EEECCCCCHHHCCCC	43.70	27180971
448	Phosphorylation	GEELDENYVPMNPNS HHHCCCCCCCCCCCC	12.13	10734310
455	Phosphorylation	YVPMNPNSPPRQHSG CCCCCCCCCCCCCCC	37.22	25521595
461	Phosphorylation	NSPPRQHSGSFTEPI CCCCCCCCCCCCCCC	28.00	23684622
473	Phosphorylation	EPIQEPNYVPMTPGT CCCCCCCCCCCCCCC	19.35	10734310
477	Phosphorylation	EPNYVPMTPGTFDFS CCCCCCCCCCCCCHH	16.70	22817900
500	Phosphorylation	PAHMGFRSSPKTPPR CCCCCCCCCCCCCCC	49.05	19060867
501	Phosphorylation	AHMGFRSSPKTPPRR CCCCCCCCCCCCCCC	26.59	29899451
504	Phosphorylation	GFRSSPKTPPRRPVP CCCCCCCCCCCCCCC	41.74	23684622
541	Phosphorylation	PLDIKPLSEWEELQA CCCCCCCHHHHHHCC	49.55	29899451
552	Phosphorylation	ELQAPVRSPITRSFA HHCCCCCCCCCHHHH	22.38	25521595
555	Phosphorylation	APVRSPITRSFARDS CCCCCCCCHHHHCCC	24.52	29550500
568	Phosphorylation	DSSRFPMSPRPDSVH CCCCCCCCCCCCCCC	20.28	19050043
590	Phosphorylation	SHDSEENYVPMNPNL CCCCCCCCCCCCCCC	14.81	10734310
628	Phosphorylation	KGDKQVEYLDLDLDS CCCCCEEEEEEECCC	13.47	10734310
635	Phosphorylation	YLDLDLDSGKSTPPR EEEEECCCCCCCCCC	56.25	29895711
638	Phosphorylation	LDLDSGKSTPPRKQK EECCCCCCCCCCCCC	50.07	29895711
639	Phosphorylation	DLDSGKSTPPRKQKS ECCCCCCCCCCCCCC	40.58	27742792
646	Phosphorylation	TPPRKQKSSGSGSSM CCCCCCCCCCCCCCC	37.12	26643407
647	Phosphorylation	PPRKQKSSGSGSSMA CCCCCCCCCCCCCCC	43.97	26643407
649	Phosphorylation	RKQKSSGSGSSMADE CCCCCCCCCCCCCHH	37.13	26643407
651	Phosphorylation	QKSSGSGSSMADERV CCCCCCCCCCCHHCC	20.73	29899451
652	Phosphorylation	KSSGSGSSMADERVD CCCCCCCCCCHHCCC	22.86	26643407
660	Phosphorylation	MADERVDYVVVDQQK CCHHCCCEEEECCHH	7.71	10734310
679	Phosphorylation	KSTREAWTDGRQSTE HHHHHHHHCCCCCCC	35.31	26643407
684	Phosphorylation	AWTDGRQSTESETPT HHHCCCCCCCCCCCC	32.55	26643407
685	Phosphorylation	WTDGRQSTESETPTK HHCCCCCCCCCCCCC	34.88	26643407
687	Phosphorylation	DGRQSTESETPTKNV CCCCCCCCCCCCCCC	47.02	23375375
689	Phosphorylation	RQSTESETPTKNVK- CCCCCCCCCCCCCC-	45.60	26643407
691	Phosphorylation	STESETPTKNVK--- CCCCCCCCCCCC---	42.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
285	Y	Phosphorylation	Kinase	MET	P16056	PSP
285	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
307	Y	Phosphorylation	Kinase	MET	P16056	PSP
307	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
373	Y	Phosphorylation	Kinase	MET	P16056	PSP
373	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
407	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
407	Y	Phosphorylation	Kinase	MET	P16056	PSP
448	Y	Phosphorylation	Kinase	MET	P16056	PSP
448	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
473	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
473	Y	Phosphorylation	Kinase	MET	P16056	PSP
552	S	Phosphorylation	Kinase	ERK1	P27361	PSP
590	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
590	Y	Phosphorylation	Kinase	MET	P16056	PSP
628	Y	Phosphorylation	Kinase	MET	P16056	PSP
628	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
660	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
660	Y	Phosphorylation	Kinase	MET	P16056	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GAB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GAB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC_MOUSE	Src	physical	12808090
SHC1_MOUSE	Shc1	physical	12808090
PTN11_MOUSE	Ptpn11	physical	12808090
P85A_MOUSE	Pik3r1	physical	12808090
PTN11_MOUSE	Ptpn11	physical	15273746
PTN11_MOUSE	Ptpn11	physical	25159185
GRB2_MOUSE	Grb2	physical	25159185

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GAB1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-504, AND MASSSPECTROMETRY.	17242355 [Abstract]