FWCH1_HUMAN - dbPTM
FWCH1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FWCH1_HUMAN
UniProt AC Q4VC44
Protein Name FLYWCH-type zinc finger-containing protein 1
Gene Name FLYWCH1
Organism Homo sapiens (Human).
Sequence Length 716
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MPLPEPSEQEGESVKAGQEPSPKPGTDVIPAAPRKPREFSKLVLLTASDQDEDGVGSKPQEVHCVLSLEMAGPATLASTLQILPVEEQGGVVQPALEMPEQKCSKLDAAAPQSLEFLRTPFGGRLLVLESFLYKQEKAVGDKVYWKCRQHAELGCRGRAITRGLRATVMRGHCHAPDEQGLEARRQREKLPSLALPEGLGEPQGPEGPGGRVEEPLEGVGPWQCPEEPEPTPGLVLSKPALEEEEAPRALSLLSLPPKKRSILGLGQARPLEFLRTCYGGSFLVHESFLYKREKAVGDKVYWTCRDHALHGCRSRAITQGQRVTVMRGHCHQPDMEGLEARRQQEKAVETLQAGQDGPGSQVDTLLRGVDSLLYRRGPGPLTLTRPRPRKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVMVMRRHCHPPDLGGLEALRQREHFPNLAQWDSPDPLRPLEFLRTSLGGRFLVHESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGHRIMVMRSHCHQPDLAGLEALRQRERLPTTAQQEDPEKIQVQLCFKTCSPESQQIYGDIKDVRLDGESQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MPLPEPSEQEGESV
-CCCCCCCCCCCCCC		50.6925159151
13PhosphorylationPSEQEGESVKAGQEP
CCCCCCCCCCCCCCC		39.5125159151
13 (in isoform 5)Phosphorylation-39.5126503514
21PhosphorylationVKAGQEPSPKPGTDV
CCCCCCCCCCCCCCC		44.8230266825
23UbiquitinationAGQEPSPKPGTDVIP
CCCCCCCCCCCCCCC		61.4929967540
26PhosphorylationEPSPKPGTDVIPAAP
CCCCCCCCCCCCCCC		35.3029255136
73 (in isoform 5)Phosphorylation-16.7224114839
113PhosphorylationLDAAAPQSLEFLRTP
CCCCCCCCHHHHCCC		28.8928555341
119PhosphorylationQSLEFLRTPFGGRLL
CCHHHHCCCCCCEEE		25.7228555341
134SumoylationVLESFLYKQEKAVGD
EEEEHHHHHHHHHCC		54.8728112733
141UbiquitinationKQEKAVGDKVYWKCR
HHHHHHCCCCHHHHH		30.5629967540
142UbiquitinationQEKAVGDKVYWKCRQ
HHHHHCCCCHHHHHH		31.15-
146 (in isoform 3)Ubiquitination-11.23-
146UbiquitinationVGDKVYWKCRQHAEL
HCCCCHHHHHHHHHC		11.23-
188UbiquitinationLEARRQREKLPSLAL
HHHHHHHHCCCCCCC		51.0829967540
189UbiquitinationEARRQREKLPSLALP
HHHHHHHCCCCCCCC		68.81-
192PhosphorylationRQREKLPSLALPEGL
HHHHCCCCCCCCCCC		36.3925850435
261PhosphorylationSLPPKKRSILGLGQA
CCCCCCCCCCCCCCC		30.9221712546
318PhosphorylationGCRSRAITQGQRVTV
CHHHCCCCCCCCEEE		26.1822210691
350PhosphorylationQQEKAVETLQAGQDG
HHHHHHHHHHCCCCC		19.9923532336
360PhosphorylationAGQDGPGSQVDTLLR
CCCCCCCCHHHHHHH		30.1129214152
364PhosphorylationGPGSQVDTLLRGVDS
CCCCHHHHHHHCHHH		28.9228555341
371PhosphorylationTLLRGVDSLLYRRGP
HHHHCHHHHHHHCCC		20.1919691289
384PhosphorylationGPGPLTLTRPRPRKR
CCCCCEECCCCCCCC		33.1328555341
393SumoylationPRPRKRAKVEDQELP
CCCCCCCCCCCCCCC		50.63-
393SumoylationPRPRKRAKVEDQELP
CCCCCCCCCCCCCCC		50.6328112733
498PhosphorylationQREKRPNTAQRGSPG
HHHHCCCCCCCCCCC		27.1821712546
502PhosphorylationRPNTAQRGSPGGPEF
CCCCCCCCCCCCCHH		26.5524719451
503PhosphorylationPNTAQRGSPGGPEFL
CCCCCCCCCCCCHHH		23.6630266825
591PhosphorylationPNLAQWDSPDPLRPL
CCCCCCCCCCCCCCH		28.3922199227
641PhosphorylationQARLGCRSRAITQGH
HHHCCCCHHHHHHCC		30.09-
685SumoylationAQQEDPEKIQVQLCF
CCCCCHHHEEEEEEE		43.7728112733
694PhosphorylationQVQLCFKTCSPESQQ
EEEEEEEECCHHHHH		9.6630266825
695PhosphorylationVQLCFKTCSPESQQI
EEEEEEECCHHHHHH		7.0527251275
696PhosphorylationQLCFKTCSPESQQIY
EEEEEECCHHHHHHH		36.6130266825
699PhosphorylationFKTCSPESQQIYGDI
EEECCHHHHHHHCCE		30.6730266825
703PhosphorylationSPESQQIYGDIKDVR
CHHHHHHHCCEEECC		12.3830266825
706UbiquitinationSQQIYGDIKDVRLDG
HHHHHCCEEECCCCC		3.4029967540
707UbiquitinationQQIYGDIKDVRLDGE
HHHHCCEEECCCCCC		55.71-
715PhosphorylationDVRLDGESQ------
ECCCCCCCC------		46.8730576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FWCH1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FWCH1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FWCH1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SETB1_HUMANSETDB1physical
16169070
HTSF1_HUMANHTATSF1physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FWCH1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-261 AND SER-696,AND MASS SPECTROMETRY.

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