FUR2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUR2_DROME
• UniProt AC: P30432
• Protein Name: Furin-like protease 2
• Gene Name: Fur2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1679
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif..
• Protein Sequence: MSNTTRSSRVTIGRIGTTPQITDPWSSGLEKQRPSRCGGPKSLAEPTYRKIGRRKMMLHMRVHDPGTTVTQRAKETATAKLNRIYLCTFNRMAQSCIYFVLFLVILSPNTSCALRSSAGETQNYVGILSNDSATTTYDVSSLHSSRRTNPPSSSSSSSSNVDVDYRNDRELHKVDLVGLGGERAGQAETISGGKYDYNYENTHTNASAKDEIVERQSNSLDFDGVDMFGAFSIPEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRLDNTCVSRCPPRSFPNQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADKKRLECMPCQEGCKTCTSNGVCSECLQNWTLNKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEAGSLCSPCLHTCSQCVSRTNCSNCSKGLELQNGECRTTCADGYYSDRGICAKCYLSCHTCSGPRRNQCVQCPAGWQLAAGECHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSCPPHSMLDGGLCMECLSSQYYDTTSATCKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKATSTGGKRRTVVGSGSAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRNSVRYRKIANTSSGRRKNLSAKPTSDARFIFNIGEDDDTDGDNSDDELDGNVGTDINNRIVYDRKGNDHGHEFYIESTNDIDAIEFHCNGAGAQKAETQLQRCNANGDDDDILHYDRHTNAERKNHPSSTTSRTNIRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	N-linked_Glycosylation	-----MSNTTRSSRV -----CCCCCCCCCE	58.28	-
109	N-linked_Glycosylation	FLVILSPNTSCALRS HHHHHCCCCCCHHHC	41.05	-
130	N-linked_Glycosylation	NYVGILSNDSATTTY EEEEEECCCCCCEEE	43.76	-
205	N-linked_Glycosylation	NYENTHTNASAKDEI CCCCCCCCCCHHHHH	25.05	-
442	N-linked_Glycosylation	ASFDINGNDSDPTPQ CCCCCCCCCCCCCCC	40.92	-
480	N-linked_Glycosylation	CGVGVAYNASIGGVR CCCCCEEECEECCEE	19.92	-
927	N-linked_Glycosylation	TATLDGQNVTAAIAG EEEECCCEEEEEEEC	38.34	-
1060	N-linked_Glycosylation	GYFENSRNRTCVPCE CCCCCCCCCEEEECC	43.35	-
1181	N-linked_Glycosylation	VCSECLQNWTLNKRD CHHHHHHHCCCCCCC	22.28	-
1274	N-linked_Glycosylation	SQCVSRTNCSNCSKG HHHHHHCCCCCCCCC	26.55	-
1277	N-linked_Glycosylation	VSRTNCSNCSKGLEL HHHCCCCCCCCCEEE	35.96	-
1439	N-linked_Glycosylation	QCVSCCQNQTLAEKT HHHHHHCCCCHHHHH	23.92	-
1580	Phosphorylation	NIGEDDDTDGDNSDD EECCCCCCCCCCCCC	49.21	30478224
1585	Phosphorylation	DDTDGDNSDDELDGN CCCCCCCCCCCCCCC	51.70	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUR2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUR2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUR2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCM2_DROME	gcm2	physical	14605208
RAB26_DROME	Rab26	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.