FSIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FSIP1_HUMAN
• UniProt AC: Q8NA03
• Protein Name: Fibrous sheath-interacting protein 1
• Gene Name: FSIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Protein Sequence: MDIIKGNLDGISKPASNSRIRPGSRSSNASLEVLSTEPGSFKVDTASNLNSGKEDHSESSNTENRRTSNDDKQESCSEKIKLAEEGSDEDLDLVQHQIISECSDEPKLKELDSQLQDAIQKMKKLDKILAKKQRREKEIKKQGLEMRIKLWEEIKSAKYSEAWQSKEEMENTKKFLSLTAVSEETVGPSHEEEDTFSSVFHTQIPPEEYEMQMQKLNKDFTCDVERNESLIKSGKKPFSNTEKIELRGKHNQDFIKRNIELAKESRNPVVMVDREKKRLVELLKDLDEKDSGLSSSEGDQSGWVVPVKGYELAVTQHQQLAEIDIKLQELSAASPTISSFSPRLENRNNQKPDRDGERNMEVTPGEKILRNTKEQRDLHNRLREIDEKLKMMKENVLESTSCLSEEQLKCLLDECILKQKSIIKLSSERKKEDIEDVTPVFPQLSRSIISKLLNESETKVQKTEVEDADMLESEECEASKGYYLTKALTGHNMSEALVTEAENMKCLQFSKDVIISDTKDYFMSKTLGIGRLKRPSFLDDPLYGISVSLSSEDQHLKLSSPENTIADEQETKDAAEECKEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KGNLDGISKPASNSR CCCCCCCCCCCCCCC	37.81	30631047
24	Phosphorylation	NSRIRPGSRSSNASL CCCCCCCCCCCCCCE	31.50	-
36	Phosphorylation	ASLEVLSTEPGSFKV CCEEEEECCCCCEEE	41.88	-
87	Phosphorylation	IKLAEEGSDEDLDLV HHHHHCCCHHHHHHH	40.90	30576142
113	Phosphorylation	PKLKELDSQLQDAIQ HHHHHHHHHHHHHHH	45.47	18452278
127	Ubiquitination	QKMKKLDKILAKKQR HHHHHHHHHHHHHHH	50.48	-
156	Phosphorylation	KLWEEIKSAKYSEAW HHHHHHHHHHHHHHH	35.34	-
160	O-linked_Glycosylation	EIKSAKYSEAWQSKE HHHHHHHHHHHHCHH	21.82	30379171
160	Phosphorylation	EIKSAKYSEAWQSKE HHHHHHHHHHHHCHH	21.82	-
165	Phosphorylation	KYSEAWQSKEEMENT HHHHHHHCHHHHHHH	31.19	-
229	Phosphorylation	CDVERNESLIKSGKK CCHHHCHHHHHCCCC	38.65	24719451
233	Phosphorylation	RNESLIKSGKKPFSN HCHHHHHCCCCCCCC	49.18	22673903
239	Phosphorylation	KSGKKPFSNTEKIEL HCCCCCCCCCCCCCC	51.90	22673903
241	Phosphorylation	GKKPFSNTEKIELRG CCCCCCCCCCCCCCC	37.14	22673903
265	Phosphorylation	NIELAKESRNPVVMV HHHHHHHHCCCEEEE	36.33	29978859
310	Phosphorylation	WVVPVKGYELAVTQH CEEEECCCEEEEECC	11.31	24043423
315	Phosphorylation	KGYELAVTQHQQLAE CCCEEEEECCHHHHH	18.09	24043423
331	Phosphorylation	DIKLQELSAASPTIS HHHHHHHHCCCCCHH	22.49	24043423
334	Phosphorylation	LQELSAASPTISSFS HHHHHCCCCCHHHCC	23.46	28857561
336	Phosphorylation	ELSAASPTISSFSPR HHHCCCCCHHHCCCC	30.88	24043423
338	Phosphorylation	SAASPTISSFSPRLE HCCCCCHHHCCCCHH	28.01	24043423
339	Phosphorylation	AASPTISSFSPRLEN CCCCCHHHCCCCHHC	26.37	24719451
341	Phosphorylation	SPTISSFSPRLENRN CCCHHHCCCCHHCCC	15.85	25850435
363	Phosphorylation	GERNMEVTPGEKILR CCCCCCCCCHHHHHH	16.57	-
399	Phosphorylation	MKENVLESTSCLSEE HHHHHHHCCCCCCHH	22.81	26074081
400	Phosphorylation	KENVLESTSCLSEEQ HHHHHHCCCCCCHHH	17.68	26074081
401	Phosphorylation	ENVLESTSCLSEEQL HHHHHCCCCCCHHHH	23.49	26074081
404	Phosphorylation	LESTSCLSEEQLKCL HHCCCCCCHHHHHHH	43.33	26074081
421	Phosphorylation	ECILKQKSIIKLSSE HHHHHCHHHHHHCCH	27.35	24719451
447	Phosphorylation	VFPQLSRSIISKLLN CCHHHHHHHHHHHHC	22.39	22210691
450	Phosphorylation	QLSRSIISKLLNESE HHHHHHHHHHHCCCC	18.64	-
510	Phosphorylation	NMKCLQFSKDVIISD HCCHHHCCCCEEEEC	18.26	27461979
516	Phosphorylation	FSKDVIISDTKDYFM CCCCEEEECCCHHHH	28.27	27461979
518	Phosphorylation	KDVIISDTKDYFMSK CCEEEECCCHHHHHC	21.01	27461979
536	Phosphorylation	IGRLKRPSFLDDPLY CCCCCCCHHCCCCCC	42.34	-
543	Phosphorylation	SFLDDPLYGISVSLS HHCCCCCCEEEEECC	20.15	-
548	Phosphorylation	PLYGISVSLSSEDQH CCCEEEEECCCCCCC	18.75	-
559	Phosphorylation	EDQHLKLSSPENTIA CCCCCCCCCCCCCCC	42.11	22199227
560	Phosphorylation	DQHLKLSSPENTIAD CCCCCCCCCCCCCCC	46.82	21815630
564	Phosphorylation	KLSSPENTIADEQET CCCCCCCCCCCHHHH	18.84	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FSIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FSIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FSIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.