FMN1_MOUSE - dbPTM
FMN1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FMN1_MOUSE
UniProt AC Q05860
Protein Name Formin-1
Gene Name Fmn1
Organism Mus musculus (Mouse).
Sequence Length 1466
Subcellular Localization Nucleus. Cytoplasm. Cell junction, adherens junction. Cell membrane
Peripheral membrane protein
Cytoplasmic side. Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctio
Protein Description Plays a role in the formation of adherens junction and the polymerization of linear actin cables..
Protein Sequence MEGTHCTLQLHNPIAELCYISFYLPKGEVRGFSYKGTVTLDRSNNAFHNCYQVREGPDITSLSQQPNEHPGDIFFKQTPTKNILTELYKLTAEKERLLDSLLRSDNILGVSMGSQEGKLQELSVILATGDEYFQSAGNWRRELPVSSLIRRSTQENKKPRRSGRRRESPEELRQKRTRRKGRGCQESAFQMGKDQVCSSSSLSFRARPNLRLLEERGNLVPRGTLTSSLRRRESCPANILRTPDADLAFGNSGRTSEDTDLEGPLSPDSSPTEVGDADVGGQLKSSHQQEPPQPNVSESHGKHAGAERWSSRTRKSKSLERTCSKKPVSKVVAKIQEPSAPVKRIVRAHHDGKGRVAYGPETQTEFIPKADFLTLPGGETETHSSGRLEEEQPGIKSLRSSAPERASITKEPASTEAAVNKVLRKVIESEKLDEATEGKRLGFSLNTRATHTFPETRSQRKAGLPQSGHKFLLLDLPHTVGPDSPQPKCDEKKPTPQVPTALGMVFNNSSPQSSAHKRLSPVPSPLSPRCPSPQQHHRILLLPPLPSEGEVVFNEYPSRKNDVSSGFPSADTLEPSSTTKVTETKGASPTSLRASQTWLVSEEASEKGLGPEKITAPPQHQLPPGIASEGFPCDNFKEQTAKDLPNKDGGVWVPGYRAGPPCPFLLHEEKEKTSRSELYLDLNPDQSPTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIETLQAQFELKTFHIRGEHALVTARLEEAIENLKQQLGKRREGCEEMRDVCISTDDDCSPKAFRNVCIQTDRETFLKPCDAESKATRSSQIVPKKLTISLTQLSPSKDSKDIHAPFQTREGTSSSSQHKISPPAPPTPPPLPPPLIPPPPPLPPGLGPLPPAPPIPPVCPVSPPPPPPPPPPTPVPPSDGPPPPPPPPPPLPNVLALPNSGGPPPPPPPPPPGLAPPPPPGLSFGLSSSSSQYPRKPAIEPSCPMKPLYWTRIQINDKSQDAAPTLWDSLEEPHIRDTSEFEYLFSKDTTQQKKKPLSEAYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFTVDDSVVDLETLAALYENRAQEDELTKIRKYYETSKEEDLKLLDKPEQFLHELAQIPNFAERAQCIIFRAVFSEGITSLHRKVEIVTRASKGLLHMKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGMNLVDYVVKYYLRYYDQCKHHDQEASCRGKDLFSLYFHIAVHPQRKSGLELKQEAGTDKSVFPLPEPQDFFLASQVKFEDLLKDLRKLKRQLEASEQQMKLVCKESPREYLQPFKDKLEEFFKKAKKEHKMEESHLENAQKSFETTVGYFGMKPKTGEKEVTPSYVFMVWFEFCSDFKTIWKRESKNISKERLKMAQASVSKLTSEKKVETKKINPTASLKERLRQKEASVATN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationRGFSYKGTVTLDRSN
CCEEEEEEEEEECCC		13.2324759943
47 (in isoform 5)Phosphorylation-4.6525338131
62 (in isoform 5)Phosphorylation-3.9225338131
91PhosphorylationLTELYKLTAEKERLL
HHHHHHHHHHHHHHH		28.7222942356
168PhosphorylationRSGRRRESPEELRQK
CCCCCCCCHHHHHHH		35.4825521595
224 (in isoform 5)Phosphorylation-28.3029233185
228PhosphorylationPRGTLTSSLRRRESC
CCCCHHHHHHCHHCC		22.2123140645
230 (in isoform 5)Phosphorylation-37.2426824392
234PhosphorylationSSLRRRESCPANILR
HHHHCHHCCCCCCCC		24.4829899451
324 (in isoform 5)Phosphorylation-43.0025168779
327 (in isoform 5)Phosphorylation-39.0727149854
372 (in isoform 5)Phosphorylation-7.2029550500
373 (in isoform 5)Phosphorylation-5.0429550500
374 (in isoform 5)Phosphorylation-30.7929550500
381 (in isoform 5)Phosphorylation-39.9723375375
396 (in isoform 5)Phosphorylation-49.7229514104
399 (in isoform 5)Phosphorylation-35.3427149854
446 (in isoform 5)Phosphorylation-26.7326824392
451 (in isoform 5)Phosphorylation-25.2430635358
453 (in isoform 5)Phosphorylation-3.9030635358
457 (in isoform 5)Phosphorylation-29.1830635358
461 (in isoform 5)Phosphorylation-38.8925195567
463 (in isoform 5)Phosphorylation-40.7130635358
469 (in isoform 5)Phosphorylation-23.9625159016
500PhosphorylationKPTPQVPTALGMVFN
CCCCCCCCHHHHHCC		35.3428059163
509PhosphorylationLGMVFNNSSPQSSAH
HHHHCCCCCCCCCCC		44.4928059163
520PhosphorylationSSAHKRLSPVPSPLS
CCCCCCCCCCCCCCC		28.0825293948
524PhosphorylationKRLSPVPSPLSPRCP
CCCCCCCCCCCCCCC		38.4120139300
527PhosphorylationSPVPSPLSPRCPSPQ
CCCCCCCCCCCCCCC		17.4320139300
532PhosphorylationPLSPRCPSPQQHHRI
CCCCCCCCCCCCCEE		38.6829899451
582PhosphorylationPSSTTKVTETKGASP
CCCCCEEEECCCCCC		39.2225168779
584PhosphorylationSTTKVTETKGASPTS
CCCEEEECCCCCCCC		25.9725168779
588PhosphorylationVTETKGASPTSLRAS
EEECCCCCCCCCCHH		37.0625168779
590PhosphorylationETKGASPTSLRASQT
ECCCCCCCCCCHHEE		37.5925168779
591PhosphorylationTKGASPTSLRASQTW
CCCCCCCCCCHHEEE		21.1725168779
605PhosphorylationWLVSEEASEKGLGPE
EEECHHHHHCCCCCC		43.0220531401
673PhosphorylationLHEEKEKTSRSELYL
CCCHHCCCCCCEEEE		30.3922802335
674PhosphorylationHEEKEKTSRSELYLD
CCHHCCCCCCEEEEE		44.8922802335
689PhosphorylationLNPDQSPTEQDDRTP
CCCCCCCCCCCCCCC		52.0722802335
792PhosphorylationMRDVCISTDDDCSPK
HHHHEEECCCCCCHH		24.4429233185
797PhosphorylationISTDDDCSPKAFRNV
EECCCCCCHHHHHHH		36.1125521595
799AcetylationTDDDCSPKAFRNVCI
CCCCCCHHHHHHHEE		43.81-
835PhosphorylationQIVPKKLTISLTQLS
CCCCCEEEEEEEECC		19.8723984901
837PhosphorylationVPKKLTISLTQLSPS
CCCEEEEEEEECCCC		21.8225619855
839PhosphorylationKKLTISLTQLSPSKD
CEEEEEEEECCCCCC		22.2225619855
842PhosphorylationTISLTQLSPSKDSKD
EEEEEECCCCCCCCC		19.8125521595
844PhosphorylationSLTQLSPSKDSKDIH
EEEECCCCCCCCCCC		45.8025619855
991GlutathionylationKPAIEPSCPMKPLYW
CCCCCCCCCCCCCEE		5.8124333276
1347AcetylationREYLQPFKDKLEEFF
HHHHHHHHHHHHHHH		61.7122902405
1431PhosphorylationRLKMAQASVSKLTSE
HHHHHHHHHHHHHCC		18.1625619855
1433PhosphorylationKMAQASVSKLTSEKK
HHHHHHHHHHHCCHH		21.3225619855
1451PhosphorylationKKINPTASLKERLRQ
CCCCCCHHHHHHHHH		42.3126824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FMN1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FMN1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FMN1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABL1_MOUSEAbl1physical
8605874
FYN_MOUSEFynphysical
8605874
PR40A_MOUSEPrpf40aphysical
8605874
TCRG1_MOUSETcerg1physical
8605874
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FMN1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, AND MASSSPECTROMETRY.

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