FLT3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLT3L_HUMAN
• UniProt AC: P49771
• Protein Name: Fms-related tyrosine kinase 3 ligand
• Gene Name: FLT3LG
• Organism: Homo sapiens (Human).
• Sequence Length: 235
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
• Protein Description: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins..
• Protein Sequence: MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	N-linked_Glycosylation	CLRFVQTNISRLLQE HHHHHHHHHHHHHHH	17.10	UniProtKB CARBOHYD
142	Ubiquitination	SEQLVALKPWITRQN HHHHHHHHHHHHHCC	28.68	-
149	N-linked_Glycosylation	KPWITRQNFSRCLEL HHHHHHCCHHHHEEE	33.30	UniProtKB CARBOHYD
170	Phosphorylation	STLPPPWSPRPLEAT CCCCCCCCCCCCCCC	19.46	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLT3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLT3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLT3L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLT3L_HUMAN	FLT3LG	physical	10881197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.