FGF10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF10_HUMAN
• UniProt AC: O15520
• Protein Name: Fibroblast growth factor 10
• Gene Name: FGF10
• Organism: Homo sapiens (Human).
• Sequence Length: 208
• Subcellular Localization: Secreted .
• Protein Description: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing..
• Protein Sequence: MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	MVSPEATNSSSSSFS CCCCCCCCCCCCCCC	47.12	UniProtKB CARBOHYD
84	Phosphorylation	VRWRKLFSFTKYFLK HHHHHHHHEEEEEEE	42.30	24719451
108	Phosphorylation	TKKENCPYSILEITS CCCCCCCCEEEEEEE	15.56	24248375
114	Phosphorylation	PYSILEITSVEIGVV CCEEEEEEEEEEEEE	19.83	20036575
115	Phosphorylation	YSILEITSVEIGVVA CEEEEEEEEEEEEEE	24.34	24248375
161	Phosphorylation	ERIEENGYNTYASFN HHHHHCCCCCCEEEE	18.86	22817900
164	Phosphorylation	EENGYNTYASFNWQH HHCCCCCCEEEEEEE	9.16	22817900
196	N-linked_Glycosylation	GQKTRRKNTSAHFLP CCCCCCCCCCCCCCE	37.14	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGF10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H11_HUMAN	HIST1H1A	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
SIR1_HUMAN	SIRT1	physical	26186194
ITIH2_HUMAN	ITIH2	physical	26186194
HBD_HUMAN	HBD	physical	26186194
H11_HUMAN	HIST1H1A	physical	28514442
ITIH2_HUMAN	ITIH2	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
SIR1_HUMAN	SIRT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 180920: Aplasia of lacrimal and salivary glands (ALSG)
• 149730: Lacrimo-auriculo-dento-digital syndrome (LADDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.