FCERB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCERB_HUMAN
• UniProt AC: Q01362
• Protein Name: High affinity immunoglobulin epsilon receptor subunit beta
• Gene Name: MS4A2
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy..
• Protein Sequence: MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	ALPQEPSSVPAFEVL CCCCCCCCCCCEEEE	42.72	26657352
135	Phosphorylation	RGSLGANTASSIAGG ECCCCCCCCHHHHCC	27.64	24247654
137	Phosphorylation	SLGANTASSIAGGTG CCCCCCCHHHHCCCC	21.90	24247654
138	Phosphorylation	LGANTASSIAGGTGI CCCCCCHHHHCCCCE	17.62	24247654
146	Phosphorylation	IAGGTGITILIINLK HHCCCCEEEEEEECH	15.86	24247654
219	Phosphorylation	KVPEDRVYEELNIYS CCCHHHHHHHHCEEE	12.46	22817900
225	Phosphorylation	VYEELNIYSATYSEL HHHHHCEEEEECHHC	7.38	-
226	Phosphorylation	YEELNIYSATYSELE HHHHCEEEEECHHCC	15.44	-
229	Phosphorylation	LNIYSATYSELEDPG HCEEEEECHHCCCCC	10.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCERB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCERB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCERB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• H00079: Asthma
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00043: Omalizumab