FBX9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX9_MOUSE
• UniProt AC: Q8BK06
• Protein Name: F-box only protein 9
• Gene Name: Fbxo9
• Organism: Mus musculus (Mouse).
• Sequence Length: 437
• Subcellular Localization: Cytoplasm.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity)..
• Protein Sequence: MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Acetylation	-	34.51	17242355
2 (in isoform 3)	Acetylation	-	34.51	17242355
10	Phosphorylation	AEAEEDCHSDADRVG HHHHHHHCCCHHHCC	40.82	24719451
10 (in isoform 2)	Phosphorylation	-	40.82	17242355
10 (in isoform 3)	Phosphorylation	-	40.82	17242355
11	Phosphorylation	EAEEDCHSDADRVGD HHHHHHCCCHHHCCC	40.60	29233185
23	Phosphorylation	VGDEGNESPAERDLQ CCCCCCCCHHHHHHH	33.15	25521595
122	Phosphorylation	PDIEFKITYTRSPDG CCEEEEEEEEECCCC	21.30	25293948
123	Phosphorylation	DIEFKITYTRSPDGD CEEEEEEEEECCCCC	12.02	25293948
124	Phosphorylation	IEFKITYTRSPDGDG EEEEEEEEECCCCCC	18.93	25293948
126	Phosphorylation	FKITYTRSPDGDGVG EEEEEEECCCCCCCC	21.39	25521595
134	Phosphorylation	PDGDGVGSGYIEENE CCCCCCCCCEEECCC	26.47	21082442
265	Phosphorylation	GVYISKTTYIRQGEQ EEEEECCEEEEECCC	22.23	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARG_MOUSE	Pparg	physical	27197753

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.