| UniProt ID | FBW12_HUMAN | |
|---|---|---|
| UniProt AC | Q6X9E4 | |
| Protein Name | F-box/WD repeat-containing protein 12 | |
| Gene Name | FBXW12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 464 | |
| Subcellular Localization | ||
| Protein Description | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.. | |
| Protein Sequence | MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSILVMYSLNT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | DSDYLWRSLSLQRWD CCHHHHHHHCCCEEC | 15.66 | 22496350 | |
| 46 | Phosphorylation | DYLWRSLSLQRWDCS HHHHHHHCCCEECCC | 24.57 | 24719451 | |
| 103 | Phosphorylation | AFETELAYLSGNRLT EEEEEEEHHCCCCEE | 17.64 | 22817900 | |
| 292 | Ubiquitination | ASACWTPKVKNRITL HHHCCCHHHCCEEEE | 59.47 | - | |
| 298 | Phosphorylation | PKVKNRITLMSQSST HHHCCEEEEEEECCC | 17.11 | 29449344 | |
| 301 | Phosphorylation | KNRITLMSQSSTGKK CCEEEEEEECCCCCC | 29.98 | 29449344 | |
| 303 | Phosphorylation | RITLMSQSSTGKKTE EEEEEEECCCCCCEE | 23.66 | 29449344 | |
| 304 | Phosphorylation | ITLMSQSSTGKKTEF EEEEEECCCCCCEEE | 33.28 | 29449344 | |
| 305 | Phosphorylation | TLMSQSSTGKKTEFI EEEEECCCCCCEEEE | 59.26 | 25247763 | |
| 358 | Phosphorylation | DGYMIVFTSGPYLLL CCEEEEEECCCEEEE | 23.14 | 26074081 | |
| 359 | Phosphorylation | GYMIVFTSGPYLLLF CEEEEEECCCEEEEE | 26.72 | 26074081 | |
| 362 | Phosphorylation | IVFTSGPYLLLFSIT EEEECCCEEEEEEHH | 17.32 | 26074081 | |
| 455 | Phosphorylation | VRKVSDSSILVMYSL EEEECCCEEEEEEEC | 25.57 | 24114839 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBW12_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBW12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBW12_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| I22R1_HUMAN | IL22RA1 | physical | 26171402 | |
| SKP1_HUMAN | SKP1 | physical | 26171402 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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