FBLN7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBLN7_HUMAN
• UniProt AC: Q53RD9
• Protein Name: Fibulin-7
• Gene Name: FBLN7
• Organism: Homo sapiens (Human).
• Sequence Length: 439
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation..
• Protein Sequence: MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKSRLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTAAPEGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDRSFQANHVSKVTIFVSPYDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVPSSPRALFL ----CCCCCHHHHHH	41.38	-
5	Phosphorylation	---MVPSSPRALFLL ---CCCCCHHHHHHH	16.60	-
124	N-linked_Glycosylation	SSVVCLPNGTWTGEQ CCEEECCCCCEECCC	47.80	UniProtKB CARBOHYD
177	O-linked_Glycosylation	RCQHQAQTAAPEGSV CCHHCCCCCCCCCCC	28.01	OGP
307	N-linked_Glycosylation	ECPEGSGNVSYVKTS CCCCCCCCEEEEECC	22.66	UniProtKB CARBOHYD
336	Phosphorylation	PCRHLPKTISFHYLS CCCCCCCEEEEEEEC	21.66	-
338	Phosphorylation	RHLPKTISFHYLSLP CCCCCEEEEEEECCC	15.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBLN7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBLN7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBLN7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRP78_HUMAN	HSPA5	physical	26186194
ASPH_HUMAN	ASPH	physical	26186194
TXD11_HUMAN	TXNDC11	physical	26186194
ICLN_HUMAN	CLNS1A	physical	26186194
EDEM2_HUMAN	EDEM2	physical	26186194
ASPH_HUMAN	ASPH	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442
TXD11_HUMAN	TXNDC11	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.