FABPL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FABPL_MOUSE
• UniProt AC: P12710
• Protein Name: Fatty acid-binding protein, liver
• Gene Name: Fabp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 127
• Subcellular Localization: Cytoplasm.
• Protein Description: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport..
• Protein Sequence: MNFSGKYQLQSQENFEPFMKAIGLPEDLIQKGKDIKGVSEIVHEGKKIKLTITYGPKVVRNEFTLGEECELETMTGEKVKAVVKLEGDNKMVTTFKGIKSVTELNGDTITNTMTLGDIVYKRVSKRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNFSGKYQ -------CCCCCCCC	11.73	-
6	Acetylation	--MNFSGKYQLQSQE --CCCCCCCCCCCCC	28.73	21728379
6	Ubiquitination	--MNFSGKYQLQSQE --CCCCCCCCCCCCC	28.73	-
6	Malonylation	--MNFSGKYQLQSQE --CCCCCCCCCCCCC	28.73	26320211
7	Phosphorylation	-MNFSGKYQLQSQEN -CCCCCCCCCCCCCC	20.27	22324799
11	Phosphorylation	SGKYQLQSQENFEPF CCCCCCCCCCCCHHH	48.32	25521595
20	Acetylation	ENFEPFMKAIGLPED CCCHHHHHHHCCCHH	36.91	23954790
20	Ubiquitination	ENFEPFMKAIGLPED CCCHHHHHHHCCCHH	36.91	-
20	Malonylation	ENFEPFMKAIGLPED CCCHHHHHHHCCCHH	36.91	26073543
31	Acetylation	LPEDLIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	23864654
31	Ubiquitination	LPEDLIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	-
31	Succinylation	LPEDLIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	23806337
31	Succinylation	LPEDLIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	-
31	Malonylation	LPEDLIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	26320211
33	Ubiquitination	EDLIQKGKDIKGVSE HHHHHCCCCCCCHHH	64.41	22790023
36	Acetylation	IQKGKDIKGVSEIVH HHCCCCCCCHHHHEE	64.49	23954790
36	Succinylation	IQKGKDIKGVSEIVH HHCCCCCCCHHHHEE	64.49	23806337
36	Ubiquitination	IQKGKDIKGVSEIVH HHCCCCCCCHHHHEE	64.49	-
36	Succinylation	IQKGKDIKGVSEIVH HHCCCCCCCHHHHEE	64.49	-
36	Malonylation	IQKGKDIKGVSEIVH HHCCCCCCCHHHHEE	64.49	26320211
39	Phosphorylation	GKDIKGVSEIVHEGK CCCCCCHHHHEECCC	30.21	23984901
46	Malonylation	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	26073543
46	Succinylation	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	-
46	Succinylation	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	23806337
46	Acetylation	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	23864654
46	Glutarylation	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	24703693
46	Ubiquitination	SEIVHEGKKIKLTIT HHHEECCCEEEEEEE	48.63	-
47	Malonylation	EIVHEGKKIKLTITY HHEECCCEEEEEEEE	56.80	25418362
49	Malonylation	VHEGKKIKLTITYGP EECCCEEEEEEEECC	48.75	26320211
49	Succinylation	VHEGKKIKLTITYGP EECCCEEEEEEEECC	48.75	-
49	Acetylation	VHEGKKIKLTITYGP EECCCEEEEEEEECC	48.75	23806337
49	Ubiquitination	VHEGKKIKLTITYGP EECCCEEEEEEEECC	48.75	-
51	Phosphorylation	EGKKIKLTITYGPKV CCCEEEEEEEECCEE	13.28	23984901
53	Phosphorylation	KKIKLTITYGPKVVR CEEEEEEEECCEEEE	19.72	23984901
54	Phosphorylation	KIKLTITYGPKVVRN EEEEEEEECCEEEEC	27.81	17242355
57	Ubiquitination	LTITYGPKVVRNEFT EEEEECCEEEECEEE	49.34	-
57	Succinylation	LTITYGPKVVRNEFT EEEEECCEEEECEEE	49.34	-
57	Acetylation	LTITYGPKVVRNEFT EEEEECCEEEECEEE	49.34	23864654
57	Malonylation	LTITYGPKVVRNEFT EEEEECCEEEECEEE	49.34	26320211
57	Succinylation	LTITYGPKVVRNEFT EEEEECCEEEECEEE	49.34	23806337
64	Phosphorylation	KVVRNEFTLGEECEL EEEECEEECCCCEEE	27.89	23567750
69	S-nitrosylation	EFTLGEECELETMTG EEECCCCEEEEECCC	6.69	22178444
78	Ubiquitination	LETMTGEKVKAVVKL EEECCCCEEEEEEEE	50.83	-
78	Acetylation	LETMTGEKVKAVVKL EEECCCCEEEEEEEE	50.83	23806337
78	Succinylation	LETMTGEKVKAVVKL EEECCCCEEEEEEEE	50.83	-
78	Malonylation	LETMTGEKVKAVVKL EEECCCCEEEEEEEE	50.83	26320211
78	Succinylation	LETMTGEKVKAVVKL EEECCCCEEEEEEEE	50.83	23806337
80	Ubiquitination	TMTGEKVKAVVKLEG ECCCCEEEEEEEEEC	46.67	22790023
84	Glutarylation	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	24703693
84	Ubiquitination	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	-
84	Malonylation	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	26073543
84	Succinylation	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	-
84	Acetylation	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	23576753
84	Succinylation	EKVKAVVKLEGDNKM CEEEEEEEEECCCCE	33.93	23806337
90	Succinylation	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	23806337
90	Acetylation	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	23864654
90	Ubiquitination	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	-
90	Succinylation	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	-
90	Glutarylation	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	24703693
90	Malonylation	VKLEGDNKMVTTFKG EEEECCCCEEEEEEC	39.21	26073543
93	Phosphorylation	EGDNKMVTTFKGIKS ECCCCEEEEEECCCE	24.02	20469934
94	Phosphorylation	GDNKMVTTFKGIKSV CCCCEEEEEECCCEE	16.37	23140645
96	Succinylation	NKMVTTFKGIKSVTE CCEEEEEECCCEEEE	58.60	-
96	Ubiquitination	NKMVTTFKGIKSVTE CCEEEEEECCCEEEE	58.60	-
96	Phosphoglycerylation	NKMVTTFKGIKSVTE CCEEEEEECCCEEEE	58.60	-
96	Malonylation	NKMVTTFKGIKSVTE CCEEEEEECCCEEEE	58.60	26320211
96	Acetylation	NKMVTTFKGIKSVTE CCEEEEEECCCEEEE	58.60	23864654
99	Ubiquitination	VTTFKGIKSVTELNG EEEEECCCEEEEECC	47.76	-
99	Acetylation	VTTFKGIKSVTELNG EEEEECCCEEEEECC	47.76	22733758
99	Malonylation	VTTFKGIKSVTELNG EEEEECCCEEEEECC	47.76	26320211
100	Phosphorylation	TTFKGIKSVTELNGD EEEECCCEEEEECCC	32.14	25521595
102	Phosphorylation	FKGIKSVTELNGDTI EECCCEEEEECCCEE	41.67	19060867
108	Phosphorylation	VTELNGDTITNTMTL EEEECCCEECCCEEH	30.97	23984901
110	Phosphorylation	ELNGDTITNTMTLGD EECCCEECCCEEHHH	27.08	23140645
112	Phosphorylation	NGDTITNTMTLGDIV CCCEECCCEEHHHHH	11.68	23984901
121	Acetylation	TLGDIVYKRVSKRI- EHHHHHHHHHHCCC-	35.11	23806337
121	Malonylation	TLGDIVYKRVSKRI- EHHHHHHHHHHCCC-	35.11	26320211
121	Succinylation	TLGDIVYKRVSKRI- EHHHHHHHHHHCCC-	35.11	23806337
121	Ubiquitination	TLGDIVYKRVSKRI- EHHHHHHHHHHCCC-	35.11	-
121	Succinylation	TLGDIVYKRVSKRI- EHHHHHHHHHHCCC-	35.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FABPL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FABPL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FABPL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARA_MOUSE	Ppara	physical	11226238

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.