dbPTM

FAAH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAAH1_HUMAN
UniProt AC	O00519
Protein Name	Fatty-acid amide hydrolase 1
Gene Name	FAAH
Organism	Homo sapiens (Human).
Sequence Length	579
Subcellular Localization	Endomembrane system Single-pass membrane protein . Cytoplasm, cytoskeleton . Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
Protein Description	Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates..
Protein Sequence	MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	QLVQKLHSRELAPEA HHHHHHHHCCCCCCC	37.58	-
99	Phosphorylation	APEAVLFTYVGKAWE CCCCEEEEEECCCEE	17.09	20058876
241	Phosphorylation	LGTDIGGSIRFPSSF CCCCCCCCEECCCCC	12.84	12060782
289	Phosphorylation	PMARDVESLALCLRA CCCCCHHHHHHHHHH	20.84	24667141
329	Phosphorylation	SQPLRVGYYETDNYT CCCEEEEEEECCCCC	8.69	22817900
330	Phosphorylation	QPLRVGYYETDNYTM CCEEEEEEECCCCCC	13.36	24043423
332	Phosphorylation	LRVGYYETDNYTMPS EEEEEEECCCCCCCC	17.27	24043423
335	Phosphorylation	GYYETDNYTMPSPAM EEEECCCCCCCCHHH	13.76	22817900
336	Phosphorylation	YYETDNYTMPSPAMR EEECCCCCCCCHHHH	28.94	24043423
339	Phosphorylation	TDNYTMPSPAMRRAV CCCCCCCCHHHHHHH	17.92	24043423
406	Phosphorylation	PCLGDLVSILKLPQW HHHHHHHHHHHHHHH	29.51	24719451
423	Ubiquitination	GLLAFLVKPLLPRLS HHHHHHHHHHHHHHH	31.90	-
430	Phosphorylation	KPLLPRLSAFLSNMK HHHHHHHHHHHHHCC	20.46	-
434	Phosphorylation	PRLSAFLSNMKSRSA HHHHHHHHHCCCCCC	28.55	-
440	Phosphorylation	LSNMKSRSAGKLWEL HHHCCCCCCHHHHHH	48.76	-
454	Phosphorylation	LQHEIEVYRKTVIAQ HHHHHHHHHHHHHHH	8.13	-
488	Phosphorylation	LNAPGRATGAVSYTM CCCCCCCCCCCCHHH	25.06	22210691
493	Phosphorylation	RATGAVSYTMLYNCL CCCCCCCHHHHHHHH	6.92	22210691
513	Phosphorylation	VVPVTTVTAEDEAQM EEEEEEEECCHHHHH	23.41	22210691
573	Phosphorylation	REVERLMTPEKQSS- HHHHHHCCCCHHCC-	32.65	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FAAH1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FAAH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FAAH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00818	Propofol
DB00599	Thiopental

Regulatory Network of FAAH1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-329 AND TYR-335, ANDMASS SPECTROMETRY.	18083107 [Abstract]