FA53A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA53A_HUMAN
• UniProt AC: Q6NSI3
• Protein Name: Protein FAM53A {ECO:0000305}
• Gene Name: FAM53A {ECO:0000312|HGNC:HGNC:31860}
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Nucleus . Subnuclear distribution.
• Protein Description: May play an important role in neural development; the dorsomedial roof of the third ventricle..
• Protein Sequence: MVTLITEKLQSQSLDDLTCKAEAGPLQYSAETLNKSGRLFPLELNDQSPWKVFSGGPPVRSQAATGPDFSFLPGLSAAAHTMGLQWQPQSPRPGAGLGAASTVDPSESTGSSTAPPTKRHCRSLSEPEELVRCRSPWRPGSSKVWTPVSKRRCDSGGSATRQGSPGAVLPRSAVWSTGPTSPATPRPSSASGGFVDSSEGSAGSGPLWCSAESCLPSTRRRPSLSQERLAGAGTPLPWASSSPTSTPALGGRRGLLRCRSQPCVLSGKRSRRKRRREEDARWTRPSLDFLKMTQTLKNSKSLCSLNYEDDDEDDTPVKTVLSSPCDSRGLPGITMPGCSQRGLRTSPVHPNLWASRESVTSDGSRRSSGDPRDGDSVGEEGVFPRARWELDLEQIENN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LITEKLQSQSLDDLT ECHHHHHCCCCCCCC	31.97	28450419
13	Phosphorylation	TEKLQSQSLDDLTCK HHHHHCCCCCCCCCE	38.73	28450419
28	Phosphorylation	AEAGPLQYSAETLNK ECCCCCEEEEEEECC	19.96	25332170
32	Phosphorylation	PLQYSAETLNKSGRL CCEEEEEEECCCCCE	35.03	25332170
123	Phosphorylation	PTKRHCRSLSEPEEL CCHHHCCCCCCCHHH	41.46	23186163
125	Phosphorylation	KRHCRSLSEPEELVR HHHCCCCCCCHHHHC	52.96	28450419
164	Phosphorylation	GSATRQGSPGAVLPR CCCCCCCCCCCCCCC	16.30	28348404
223	Phosphorylation	PSTRRRPSLSQERLA CCCCCCCCCCHHHHC	38.55	-
234	Phosphorylation	ERLAGAGTPLPWASS HHHCCCCCCCCCCCC	22.55	22617229
240	Phosphorylation	GTPLPWASSSPTSTP CCCCCCCCCCCCCCC	27.72	28348404
241	Phosphorylation	TPLPWASSSPTSTPA CCCCCCCCCCCCCCC	32.37	28348404
242	Phosphorylation	PLPWASSSPTSTPAL CCCCCCCCCCCCCCC	29.69	22617229
260	Phosphorylation	RGLLRCRSQPCVLSG CCCCCCCCCCCCCCC	41.94	32645325
301	Phosphorylation	QTLKNSKSLCSLNYE HHHHCCCCCCCCCCC	34.13	28450419
304	Phosphorylation	KNSKSLCSLNYEDDD HCCCCCCCCCCCCCC	25.58	28450419
345	Phosphorylation	CSQRGLRTSPVHPNL CCCCCCCCCCCCCCC	42.28	22468782
346	Phosphorylation	SQRGLRTSPVHPNLW CCCCCCCCCCCCCCC	20.63	22617229
355	Phosphorylation	VHPNLWASRESVTSD CCCCCCCCCCEECCC	25.62	23312004
360	Phosphorylation	WASRESVTSDGSRRS CCCCCEECCCCCCCC	30.31	22468782
364	Phosphorylation	ESVTSDGSRRSSGDP CEECCCCCCCCCCCC	29.52	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA53A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA53A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA53A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.