F126B_HUMAN - dbPTM
F126B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID F126B_HUMAN
UniProt AC Q8IXS8
Protein Name Protein FAM126B
Gene Name FAM126B
Organism Homo sapiens (Human).
Sequence Length 530
Subcellular Localization Cytoplasm, cytosol . Cell membrane .
Protein Description Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane..
Protein Sequence MLGTDRCVVEEWLSEFKALPDTQITSYAATLHRKKTLVPALYKVIQDSNNELLEPVCHQLFELYRSSEVRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNNKVLSFTIPSLSKPSIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPRQHEKHWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKVLKVEVTPTVPRISRTAITTASIRRHRWRREGAEGVNGGEESVNLNDADEGFSSGASLSSQPIGTKPSSSSQRGSLRKVATGRSAKDKETASAIKSSESPRDSVVRKQYVQQPTDLSVDSVELTPMKKHLSLPAGQVVPKINSLSLIRTASASSSKSFDYVNGSQASTSIGVGTEGGTNLAANNANRYSTVSLQEDRLGQAGEGKELLSPGAPLTKQSRSPSFNMQLISQV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLGTDRCVVEE
----CCCCCCHHHHH		19.1326074081
14PhosphorylationCVVEEWLSEFKALPD
HHHHHHHHHHHCCCC		41.9026074081
22PhosphorylationEFKALPDTQITSYAA
HHHCCCCCCCCHHHH		21.6728387310
25PhosphorylationALPDTQITSYAATLH
CCCCCCCCHHHHHHH		13.0827080861
26PhosphorylationLPDTQITSYAATLHR
CCCCCCCHHHHHHHC		17.8827080861
27PhosphorylationPDTQITSYAATLHRK
CCCCCCHHHHHHHCC		7.5127080861
30PhosphorylationQITSYAATLHRKKTL
CCCHHHHHHHCCCCH		18.2228387310
42PhosphorylationKTLVPALYKVIQDSN
CCHHHHHHHHHHCCC		12.81-
97PhosphorylationTVSRDRQSNGCIEAL
HCCCCHHCCCHHHHH		35.76-
129PhosphorylationVLSFTIPSLSKPSIY
EEEEEECCCCCCCCC		41.2322210691
134PhosphorylationIPSLSKPSIYHEPST
ECCCCCCCCCCCCCC		39.2420562096
136PhosphorylationSLSKPSIYHEPSTIG
CCCCCCCCCCCCCHH		12.4120562096
162PhosphorylationHDLIRVVYSDLHPQR
HHHHHHHHCCCCCCC		8.1327642862
299UbiquitinationDSTQEGQKVLKVEVT
CCCCCCCEEEEEEEE		61.46-
306PhosphorylationKVLKVEVTPTVPRIS
EEEEEEEECCCCCCC		10.3529255136
308PhosphorylationLKVEVTPTVPRISRT
EEEEEECCCCCCCCC		33.5030266825
313PhosphorylationTPTVPRISRTAITTA
ECCCCCCCCCEEEHH		25.5128348404
315PhosphorylationTVPRISRTAITTASI
CCCCCCCCEEEHHHH		18.6723186163
318PhosphorylationRISRTAITTASIRRH
CCCCCEEEHHHHHHH		17.5329978859
319PhosphorylationISRTAITTASIRRHR
CCCCEEEHHHHHHHH		16.5821712546
321PhosphorylationRTAITTASIRRHRWR
CCEEEHHHHHHHHHH		17.9723401153
341PhosphorylationGVNGGEESVNLNDAD
CCCCCCCCCCCCCCC		16.41-
367PhosphorylationQPIGTKPSSSSQRGS
CCCCCCCCCCCCCCC		44.39-
368PhosphorylationPIGTKPSSSSQRGSL
CCCCCCCCCCCCCCC		42.40-
369PhosphorylationIGTKPSSSSQRGSLR
CCCCCCCCCCCCCCC		34.52-
374PhosphorylationSSSSQRGSLRKVATG
CCCCCCCCCCHHHCC		27.47-
389PhosphorylationRSAKDKETASAIKSS
CCCCCHHHHHHHHCC		31.4928464451
391PhosphorylationAKDKETASAIKSSES
CCCHHHHHHHHCCCC		37.6428464451
395PhosphorylationETASAIKSSESPRDS
HHHHHHHCCCCCCHH		32.9728102081
396PhosphorylationTASAIKSSESPRDSV
HHHHHHCCCCCCHHH		36.7723312004
398PhosphorylationSAIKSSESPRDSVVR
HHHHCCCCCCHHHHH		27.4725849741
402PhosphorylationSSESPRDSVVRKQYV
CCCCCCHHHHHHHHC		24.6423312004
408PhosphorylationDSVVRKQYVQQPTDL
HHHHHHHHCCCCCCC		11.8523090842
413PhosphorylationKQYVQQPTDLSVDSV
HHHCCCCCCCCCCEE		45.2828450419
416PhosphorylationVQQPTDLSVDSVELT
CCCCCCCCCCEEECC		27.0428450419
419PhosphorylationPTDLSVDSVELTPMK
CCCCCCCEEECCCCC		18.4828450419
423PhosphorylationSVDSVELTPMKKHLS
CCCEEECCCCCCCCC		14.0828450419
430PhosphorylationTPMKKHLSLPAGQVV
CCCCCCCCCCCCCEE		31.8430266825
442PhosphorylationQVVPKINSLSLIRTA
CEECCCCHHHHEEEE		23.8622617229
444PhosphorylationVPKINSLSLIRTASA
ECCCCHHHHEEEECC		22.9026074081
448PhosphorylationNSLSLIRTASASSSK
CHHHHEEEECCCCCC		20.2626074081
450PhosphorylationLSLIRTASASSSKSF
HHHEEEECCCCCCCC		28.2426074081
452PhosphorylationLIRTASASSSKSFDY
HEEEECCCCCCCCCC		32.4226074081
453PhosphorylationIRTASASSSKSFDYV
EEEECCCCCCCCCCC		41.3126074081
454PhosphorylationRTASASSSKSFDYVN
EEECCCCCCCCCCCC		29.8026074081
456PhosphorylationASASSSKSFDYVNGS
ECCCCCCCCCCCCCC		25.8728348404
487PhosphorylationAANNANRYSTVSLQE
CCCCCCCCCEEECCC		14.4326657352
488PhosphorylationANNANRYSTVSLQED
CCCCCCCCEEECCCC		21.0628796482
489PhosphorylationNNANRYSTVSLQEDR
CCCCCCCEEECCCCC		12.7427794612
491PhosphorylationANRYSTVSLQEDRLG
CCCCCEEECCCCCCC		25.1525159151
496MethylationTVSLQEDRLGQAGEG
EEECCCCCCCCCCCC		39.71-
508PhosphorylationGEGKELLSPGAPLTK
CCCCCCCCCCCCCCC		33.6330266825
514PhosphorylationLSPGAPLTKQSRSPS
CCCCCCCCCCCCCCC		26.4430266825
517PhosphorylationGAPLTKQSRSPSFNM
CCCCCCCCCCCCHHC		35.9622210691
519PhosphorylationPLTKQSRSPSFNMQL
CCCCCCCCCCHHCHH		30.0926074081
521PhosphorylationTKQSRSPSFNMQLIS
CCCCCCCCHHCHHHC		30.4226074081
528PhosphorylationSFNMQLISQV-----
CHHCHHHCCC-----		33.2226074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of F126B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of F126B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of F126B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of F126B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442 AND SER-491, ANDMASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-306, AND MASSSPECTROMETRY.

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