F117A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F117A_HUMAN
• UniProt AC: Q9C073
• Protein Name: Protein FAM117A
• Gene Name: FAM117A
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Protein Sequence: MAGAAAGGRGGGAWGPGRGGAGGLRRGCSPPAPAGSPRAGLQPLRATIPFQLQQPHQRRDGGGRAASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERASSCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFVKEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDGSPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPGSPLPPASPRPPPRKDPEASKASPLPFEPWQRTPPSEEPVLFQSSLMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	13.01	25849741
9	Methylation	AGAAAGGRGGGAWGP CCCCCCCCCCCCCCC	39.40	-
18	Dimethylation	GGAWGPGRGGAGGLR CCCCCCCCCCCCCCC	43.43	-
18	Methylation	GGAWGPGRGGAGGLR CCCCCCCCCCCCCCC	43.43	-
25	Dimethylation	RGGAGGLRRGCSPPA CCCCCCCCCCCCCCC	35.90	-
25	Methylation	RGGAGGLRRGCSPPA CCCCCCCCCCCCCCC	35.90	-
26	Methylation	GGAGGLRRGCSPPAP CCCCCCCCCCCCCCC	56.35	-
29	Phosphorylation	GGLRRGCSPPAPAGS CCCCCCCCCCCCCCC	36.42	23401153
36	Phosphorylation	SPPAPAGSPRAGLQP CCCCCCCCCCCCCCC	17.20	30266825
47	Phosphorylation	GLQPLRATIPFQLQQ CCCCCEEECCEEECC	23.81	-
67	Phosphorylation	DGGGRAASVPCSVAP CCCCCCCCCCCCCCC	26.13	23401153
71	Phosphorylation	RAASVPCSVAPEKSV CCCCCCCCCCCCCCC	18.42	23403867
89	Phosphorylation	QPLQVRRTFSLDTIL CCCCEEEEEEHHHHH	13.65	28450419
91	Phosphorylation	LQVRRTFSLDTILSS CCEEEEEEHHHHHHH	25.40	28464451
94	Phosphorylation	RRTFSLDTILSSYLL EEEEEHHHHHHHHHH	29.16	28464451
97	Phosphorylation	FSLDTILSSYLLGQW EEHHHHHHHHHHCCC	17.06	28450419
98	Phosphorylation	SLDTILSSYLLGQWP EHHHHHHHHHHCCCC	19.16	28450419
99	Phosphorylation	LDTILSSYLLGQWPR HHHHHHHHHHCCCCC	11.54	28450419
126	Phosphorylation	KATQTPLSWQELEGE CCCCCCCCHHHHCCC	28.10	-
143	Phosphorylation	SSCAHKRSASWGSTD HHCCHHHHCCCCCHH	31.30	28450419
145	Phosphorylation	CAHKRSASWGSTDHR CCHHHHCCCCCHHHH	32.96	23401153
148	Phosphorylation	KRSASWGSTDHRKEI HHHCCCCCHHHHHHH	25.14	26074081
149	Phosphorylation	RSASWGSTDHRKEIS HHCCCCCHHHHHHHH	31.70	26074081
153	Acetylation	WGSTDHRKEISKLKQ CCCHHHHHHHHHHHH	56.85	18586825
159	Acetylation	RKEISKLKQQLQRTK HHHHHHHHHHHHHHH	39.47	18586833
170	Phosphorylation	QRTKLSRSGKEKERG HHHHHHHCCCCCCCC	51.33	23312004
178	Phosphorylation	GKEKERGSPLLGDHA CCCCCCCCCCCCHHH	20.70	23401153
187	Methylation	LLGDHAVRGALRASP CCCHHHHHHHHHCCC	26.00	-
193	Phosphorylation	VRGALRASPPSFPSG HHHHHHCCCCCCCCC	30.80	22115753
196	Phosphorylation	ALRASPPSFPSGSPV HHHCCCCCCCCCCCE	53.85	22115753
199	Phosphorylation	ASPPSFPSGSPVLRL CCCCCCCCCCCEEEE	50.31	23401153
201	Phosphorylation	PPSFPSGSPVLRLSP CCCCCCCCCEEEECH	19.03	22115753
207	Phosphorylation	GSPVLRLSPCLHRSL CCCEEEECHHHHHHH	13.72	23401153
213	Phosphorylation	LSPCLHRSLEGLNQE ECHHHHHHHHHHHHH	21.74	19664994
252	Phosphorylation	RAPAPPQSGSCDHPL CCCCCCCCCCCCCCE	38.15	27080861
254	Phosphorylation	PAPPQSGSCDHPLLL CCCCCCCCCCCCEEE	22.94	27080861
269	Phosphorylation	LEPGNLASSPSMSLA ECCCCCCCCCCCCCC	46.04	27080861
270	Phosphorylation	EPGNLASSPSMSLAS CCCCCCCCCCCCCCC	18.52	26074081
272	Phosphorylation	GNLASSPSMSLASPQ CCCCCCCCCCCCCCC	23.97	27080861
274	Phosphorylation	LASSPSMSLASPQPC CCCCCCCCCCCCCCC	25.73	26074081
277	Phosphorylation	SPSMSLASPQPCGLA CCCCCCCCCCCCCCC	29.39	25849741
285	Phosphorylation	PQPCGLASHEEHRGA CCCCCCCCHHHHHHH	36.15	26074081
298	Phosphorylation	GAAEELASTPNDKAS HHHHHHHCCCCCCCC	57.95	23684312
299	Phosphorylation	AAEELASTPNDKASS HHHHHHCCCCCCCCC	22.09	23401153
305	Phosphorylation	STPNDKASSPGHPAF CCCCCCCCCCCCCCC	42.69	28450419
306	Phosphorylation	TPNDKASSPGHPAFL CCCCCCCCCCCCCCC	39.50	22115753
317	Phosphorylation	PAFLEDGSPSPVLAF CCCCCCCCCCCEEEE	34.23	28450419
319	Phosphorylation	FLEDGSPSPVLAFAA CCCCCCCCCEEEEEC	29.36	22115753
327	Phosphorylation	PVLAFAASPRPNHSY CEEEEECCCCCCCCC	20.29	28450419
333	Phosphorylation	ASPRPNHSYIFKREP CCCCCCCCCEEECCC	26.94	28450419
334	Phosphorylation	SPRPNHSYIFKREPP CCCCCCCCEEECCCC	11.65	28450419
337	Ubiquitination	PNHSYIFKREPPEGC CCCCCEEECCCCCCC	46.42	29967540
346	Ubiquitination	EPPEGCEKVRVFEEA CCCCCCCEEEEEECC	39.14	29967540
354	Phosphorylation	VRVFEEATSPGPDLA EEEEECCCCCCCCCE	38.44	23401153
355	Phosphorylation	RVFEEATSPGPDLAF EEEECCCCCCCCCEE	34.60	23898821
364	Phosphorylation	GPDLAFLTSCPDKNK CCCCEEEECCCCCCC	23.10	28111955
365	Phosphorylation	PDLAFLTSCPDKNKV CCCEEEECCCCCCCE	26.29	28111955
369	Ubiquitination	FLTSCPDKNKVHFNP EEECCCCCCCEECCC	43.75	29967540
371	Ubiquitination	TSCPDKNKVHFNPTG ECCCCCCCEECCCCC	42.71	29967540
403	Phosphorylation	FIFRNCPSNPGSPLP EEEECCCCCCCCCCC	58.83	26552605
407	Phosphorylation	NCPSNPGSPLPPASP CCCCCCCCCCCCCCC	25.23	26552605
413	Phosphorylation	GSPLPPASPRPPPRK CCCCCCCCCCCCCCC	27.50	26657352
425	Phosphorylation	PRKDPEASKASPLPF CCCCCCHHCCCCCCC	27.39	23401153
426	Ubiquitination	RKDPEASKASPLPFE CCCCCHHCCCCCCCC	60.99	29967540
428	Phosphorylation	DPEASKASPLPFEPW CCCHHCCCCCCCCCC	30.61	23401153
438	Phosphorylation	PFEPWQRTPPSEEPV CCCCCCCCCCCCCCC	25.17	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F117A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F117A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F117A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMBX1_HUMAN	HMBOX1	physical	27173435
COBL1_HUMAN	COBLL1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.