EXO5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXO5_HUMAN
• UniProt AC: Q9H790
• Protein Name: Exonuclease V
• Gene Name: EXO5
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Nucleus . Cytoplasm, cytosol . Localizes to repair foci in response to DNA damage.
• Protein Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity..
• Protein Sequence: MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISLQNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASIHLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWRKGSGVLSSTLAPQVKKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	PSSESLGKDDKPISL CCHHHCCCCCCCCCC	68.96	-
110	Ubiquitination	PGFLAPEKAAVLDTG CCCCCCCCEEEECCC	40.35	29967540
116	Phosphorylation	EKAAVLDTGASIHLA CCEEEECCCCCHHHH	30.41	-
139	Ubiquitination	VTVPVTTKEDAWAIK EECEECCHHHHHHHH	44.20	29967540
159	Phosphorylation	LLIPTLQSEGHIREF HHHHHCCCCCCEEEE	48.97	22817900
198	Ubiquitination	ELELAELKTRRRPML CCHHHHHHHCCCCCC	31.33	29967540
243	Ubiquitination	ASLIHHTKLCLEKPL HHHHHHHHHHCCCCC	32.61	-
248	Ubiquitination	HTKLCLEKPLGPSVL HHHHHCCCCCCHHHH	32.37	-
356	Ubiquitination	ADICEWRKGSGVLSS HHHCHHHCCCCCCCC	59.51	-
358	Phosphorylation	ICEWRKGSGVLSSTL HCHHHCCCCCCCCCC	28.85	-
362	Phosphorylation	RKGSGVLSSTLAPQV HCCCCCCCCCCCHHH	20.90	-
363	Phosphorylation	KGSGVLSSTLAPQVK CCCCCCCCCCCHHHH	24.23	-
364	Phosphorylation	GSGVLSSTLAPQVKK CCCCCCCCCCHHHHC	24.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXO5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXO5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXO5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXO5_HUMAN	EXO5	physical	23095756

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.