ESR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESR1_ARATH
• UniProt AC: Q9SAD4
• Protein Name: Ethylene-responsive transcription factor ESR1
• Gene Name: ESR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 328
• Subcellular Localization: Nucleus .
• Protein Description: Regulates gene expression patterns in meristems and thus modulates organ development. Required for correct embryo patterning and cotyledon organogenesis. Modulates auxin signaling pathway in early embryos. Involved in the cytokinin signaling pathway that promotes shoot regeneration. Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity)..
• Protein Sequence: MEKALRNFTESTHSPDPNPLTKFFTEPTASPVSRNRKLSSKDTTVTIAGAGSSTTRYRGVRRRPWGRYAAEIRDPMSKERRWLGTFDTAEQAACAYDSAARAFRGAKARTNFTYPTAVIMPEPRFSFSNKKSSPSARCPLPSLPLDSSTQNFYGAPAAQRIYNTQSIFLRDASCSSRKTTPYNNSFNGSSSSYSASKTACVSYSENENNESFFPEESSDTGLLQEVVQEFLKKNRGVPPSPPTPPPVTSHHDNSGYFSNLTIYSENMVQETKETLSSKLDRYGNFQANDDGVRAVADGGLSLGSNEWGYQEMLMYGTQLGCTCRRSWG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	RKLSSKDTTVTIAGA CCCCCCCCEEEECCC	27.23	28295753
44	Phosphorylation	KLSSKDTTVTIAGAG CCCCCCCEEEECCCC	26.28	28295753
46	Phosphorylation	SSKDTTVTIAGAGSS CCCCCEEEECCCCCC	11.74	28295753
52	Phosphorylation	VTIAGAGSSTTRYRG EEECCCCCCCCCCCC	24.79	28295753
53	Phosphorylation	TIAGAGSSTTRYRGV EECCCCCCCCCCCCC	32.64	28295753
54	Phosphorylation	IAGAGSSTTRYRGVR ECCCCCCCCCCCCCC	19.59	28295753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR2_ARATH	DRNL	genetic	17376809
ATBH9_ARATH	PHV	physical	17376809
ATBH9_ARATH	PHV	genetic	17376809

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.