ERBIN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERBIN_MOUSE
• UniProt AC: Q80TH2
• Protein Name: Erbin {ECO:0000303|PubMed:10878805}
• Gene Name: Erbin {ECO:0000303|PubMed:10878805}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1402
• Subcellular Localization: Cell junction, hemidesmosome . Nucleus membrane . Basolateral cell membrane . Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or conce
• Protein Description: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion. [PubMed: 16203728]
• Protein Sequence: MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	ETVTTLDYSHCSLEQ EEEEEEECCCCCHHH		-
32	S-palmitoylation	TTLDYSHCSLEQVPK EEEECCCCCHHHCCH		28680068
33	Phosphorylation	TLDYSHCSLEQVPKE EEECCCCCHHHCCHH		-
47	Phosphorylation	EIFTFEKTLEELYLD HHCCHHHHHHHHHCC		20415495
52	Phosphorylation	EKTLEELYLDANQIE HHHHHHHHCCHHHHH		20415495
101	Ubiquitination	LRELDVSKNGIQEFP CHHCCCCCCCHHHCH		-
162	Ubiquitination	ANFGRLTKLQILELR CCCCCCCHHHHHHHH		-
381	Ubiquitination	NLSDNRLKNLPFSFT ECCCCCHHCCCCCHH		-
433	Phosphorylation	MFPQQPRTEDVMFIS CCCCCCCCCCCEEEC		25619855
440	Phosphorylation	TEDVMFISDNESFNP CCCCEEECCCCCCCH		21082442
444	Phosphorylation	MFISDNESFNPALWE EEECCCCCCCHHHHH		27087446
483	Phosphorylation	REGNLKRYPTPYPDE CCCCCCCCCCCCCHH		28833060
485	Phosphorylation	GNLKRYPTPYPDELK CCCCCCCCCCCHHHH		26824392
487	Phosphorylation	LKRYPTPYPDELKNM CCCCCCCCCHHHHHH		28833060
492	Ubiquitination	TPYPDELKNMVKTVQ CCCCHHHHHHHHHHH		-
496	Ubiquitination	DELKNMVKTVQTIVH HHHHHHHHHHHHHHH		-
497	Phosphorylation	ELKNMVKTVQTIVHR HHHHHHHHHHHHHHH		22871156
551	Phosphorylation	KLDEREKYMNSVQKM HHHHHHHHHHHHHHH		29514104
573	Phosphorylation	NGGNLPVTASMKLSG CCCCCCCCEEEEECC		25338131
575	Phosphorylation	GNLPVTASMKLSGNL CCCCCCEEEEECCCC		25338131
579	Phosphorylation	VTASMKLSGNLKHIV CCEEEEECCCCEEEC		29514104
595	Phosphorylation	HDDVFEESEELSSDE CHHHHHHHHHCCCHH		27087446
599	Phosphorylation	FEESEELSSDEEMKM HHHHHHCCCHHHHHH		25521595
599 (in isoform 2)	Phosphorylation	-		19144319
600	Phosphorylation	EESEELSSDEEMKMA HHHHHCCCHHHHHHH		25521595
600 (in isoform 2)	Phosphorylation	-		19144319
617	Phosphorylation	RPPLIESSINQPKVV CCCHHHHHCCCCCEE		29514104
627	Phosphorylation	QPKVVALSNNKKDDA CCCEEEECCCCCCCC		28066266
639	Phosphorylation	DDAKDADSLSDEVTH CCCCCCCCCCHHHHC		25619855
641	Phosphorylation	AKDADSLSDEVTHNS CCCCCCCCHHHHCCC		25619855
645	Phosphorylation	DSLSDEVTHNSNQNN CCCCHHHHCCCCCCC		23984901
648	Phosphorylation	SDEVTHNSNQNNSNC CHHHHCCCCCCCCCC		25619855
653	Phosphorylation	HNSNQNNSNCSSPSR CCCCCCCCCCCCCCC		25619855
656	Phosphorylation	NQNNSNCSSPSRMSD CCCCCCCCCCCCCCC		25619855
657	Phosphorylation	QNNSNCSSPSRMSDS CCCCCCCCCCCCCCC		25619855
662	Phosphorylation	CSSPSRMSDSVSLNT CCCCCCCCCCEECCC		20469934
664	Phosphorylation	SPSRMSDSVSLNTDS CCCCCCCCEECCCCC		20469934
666	Phosphorylation	SRMSDSVSLNTDSSQ CCCCCCEECCCCCCC		20469934
669	Phosphorylation	SDSVSLNTDSSQDTS CCCEECCCCCCCCCC		20469934
671	Phosphorylation	SVSLNTDSSQDTSLC CEECCCCCCCCCCCC		20469934
672	Phosphorylation	VSLNTDSSQDTSLCS EECCCCCCCCCCCCC		20469934
675	Phosphorylation	NTDSSQDTSLCSPVK CCCCCCCCCCCCCCC		20469934
676	Phosphorylation	TDSSQDTSLCSPVKQ CCCCCCCCCCCCCCC		20469934
679	Phosphorylation	SQDTSLCSPVKQTPV CCCCCCCCCCCCCCC		20469934
684	Phosphorylation	LCSPVKQTPVDSNSK CCCCCCCCCCCCCHH		20469934
688	Phosphorylation	VKQTPVDSNSKVRQE CCCCCCCCCHHHCCC		20469934
690	Phosphorylation	QTPVDSNSKVRQEDE CCCCCCCHHHCCCCC		20469934
701	Phosphorylation	QEDENFNSLLQNGVN CCCCCHHHHHHHCCC		25619855
712	Phosphorylation	NGVNLNNSPEEKFKI HCCCCCCCHHHHCCC		25521595
712 (in isoform 2)	Phosphorylation	-		19144319
751	Phosphorylation	DIDSKATSDDSRQLD CCCCCCCCCCCHHHH		25338131
790	Phosphorylation	MQDIVLGTGFLSIHP CCCEEECCCCEEECC		-
794	Phosphorylation	VLGTGFLSIHPKNEA EECCCCEEECCCCHH		-
826	Phosphorylation	VNGLCEDTAPSPGRV CCCCCCCCCCCCCCC		28066266
829	Phosphorylation	LCEDTAPSPGRVEPQ CCCCCCCCCCCCCCC		25521595
839	Phosphorylation	RVEPQKASSSADVGI CCCCCCCCCCCCCCC		25619855
840	Phosphorylation	VEPQKASSSADVGIS CCCCCCCCCCCCCCC		25521595
841	Phosphorylation	EPQKASSSADVGISK CCCCCCCCCCCCCCC		25619855
847	Phosphorylation	SSADVGISKSTEDLS CCCCCCCCCCCCCCC		27742792
849	Phosphorylation	ADVGISKSTEDLSPQ CCCCCCCCCCCCCCC		25521595
850	Phosphorylation	DVGISKSTEDLSPQR CCCCCCCCCCCCCCC		27742792
854	Phosphorylation	SKSTEDLSPQRSGPT CCCCCCCCCCCCCCC		27087446
858	Phosphorylation	EDLSPQRSGPTGAVV CCCCCCCCCCCCCEE		26745281
861	Phosphorylation	SPQRSGPTGAVVKSH CCCCCCCCCCEEEEC		25338131
867	Phosphorylation	PTGAVVKSHSITNME CCCCEEEECCCCCCC		25159016
869	Phosphorylation	GAVVKSHSITNMETG CCEEEECCCCCCCCC		25521595
869 (in isoform 2)	Phosphorylation	-		19144319
871	Phosphorylation	VVKSHSITNMETGGL EEEECCCCCCCCCCE		20469934
875	Phosphorylation	HSITNMETGGLKIYD CCCCCCCCCCEEEEE		25159016
881	Phosphorylation	ETGGLKIYDILGDDG CCCCEEEEEHHCCCC		25159016
910	Phosphorylation	DGKNIVRSKSATLLY CCCCCEECCCEEEEE		27087446
912	Phosphorylation	KNIVRSKSATLLYDQ CCCEECCCEEEEECC		27087446
914	Phosphorylation	IVRSKSATLLYDQPL CEECCCEEEEECCCC		21082442
917	Phosphorylation	SKSATLLYDQPLQVF CCCEEEEECCCCEEE		27087446
925	Phosphorylation	DQPLQVFTAASSSSE CCCCEEEEECCCCCH		23140645
928	Phosphorylation	LQVFTAASSSSELLS CEEEEECCCCCHHHC		26643407
929	Phosphorylation	QVFTAASSSSELLSG EEEEECCCCCHHHCC		30352176
930	Phosphorylation	VFTAASSSSELLSGT EEEECCCCCHHHCCC		27087446
931	Phosphorylation	FTAASSSSELLSGTK EEECCCCCHHHCCCE		27087446
935	Phosphorylation	SSSSELLSGTKAVFK CCCCHHHCCCEEEEE		26643407
937	Phosphorylation	SSELLSGTKAVFKFD CCHHHCCCEEEEEEC		26643407
945	Phosphorylation	KAVFKFDSNHNPEEP EEEEEECCCCCCCCC		25338131
970	Phosphorylation	PQSTPHLYGPPQYNV CCCCCCCCCCCCCCE		29514104
975	Phosphorylation	HLYGPPQYNVQYSGS CCCCCCCCCEEECCE		29514104
979	Phosphorylation	PPQYNVQYSGSATVK CCCCCEEECCEEEEE		29514104
980	Phosphorylation	PQYNVQYSGSATVKD CCCCEEECCEEEEEC		29514104
1011	Phosphorylation	PPQRLPRSESAENHS CCCCCCCCCCCCCCC		27087446
1013	Phosphorylation	QRLPRSESAENHSYA CCCCCCCCCCCCCHH		25521595
1018	Phosphorylation	SESAENHSYAKHSAN CCCCCCCCHHHHCCC		27717184
1019	Phosphorylation	ESAENHSYAKHSANM CCCCCCCHHHHCCCC		29514104
1038	Phosphorylation	HNNVRANTGYHLQQR CCCCCCCCCCCHHHH		27149854
1040	Phosphorylation	NVRANTGYHLQQRLA CCCCCCCCCHHHHCC		29514104
1058	Phosphorylation	HGEMWAISPNDRLVP CCCCEEECCCCCCCC		28066266
1070	Phosphorylation	LVPAVTRTTIQRQSS CCCCEEECHHHCCCC		23608596
1071	Phosphorylation	VPAVTRTTIQRQSSV CCCEEECHHHCCCCC		29514104
1076	Phosphorylation	RTTIQRQSSVSSTAS ECHHHCCCCCCCCEE		22324799
1077	Phosphorylation	TTIQRQSSVSSTASV CHHHCCCCCCCCEEE		26824392
1079	Phosphorylation	IQRQSSVSSTASVNL HHCCCCCCCCEEEEC		26643407
1080	Phosphorylation	QRQSSVSSTASVNLG HCCCCCCCCEEEECC		29899451
1081	Phosphorylation	RQSSVSSTASVNLGD CCCCCCCCEEEECCC		29899451
1083	Phosphorylation	SSVSSTASVNLGDPT CCCCCCEEEECCCCC		22324799
1090	Phosphorylation	SVNLGDPTRRTEGDY EEECCCCCCCCCCCC		22324799
1097	Phosphorylation	TRRTEGDYLSYRELH CCCCCCCCCCHHHHH		26824392
1099	Phosphorylation	RTEGDYLSYRELHSM CCCCCCCCHHHHHHC		22499769
1100	Phosphorylation	TEGDYLSYRELHSMG CCCCCCCHHHHHHCC		22499769
1113	Phosphorylation	MGRTPVMSGSQRPLS CCCCCCCCCCCCCCE		29472430
1115	Phosphorylation	RTPVMSGSQRPLSAR CCCCCCCCCCCCEEE		24759943
1120	Phosphorylation	SGSQRPLSARAYSID CCCCCCCEEEEEECC		28507225
1124	Phosphorylation	RPLSARAYSIDGPNT CCCEEEEEECCCCCC		26643407
1125	Phosphorylation	PLSARAYSIDGPNTS CCEEEEEECCCCCCC		26824392
1131	Phosphorylation	YSIDGPNTSRPQSAR EECCCCCCCCCCCCC		21183079
1132	Phosphorylation	SIDGPNTSRPQSARP ECCCCCCCCCCCCCC		26643407
1136	Phosphorylation	PNTSRPQSARPSINE CCCCCCCCCCCCHHH		26643407
1140	Phosphorylation	RPQSARPSINEIPER CCCCCCCCHHHCCCC		29514104
1148	Phosphorylation	INEIPERTMSVSDFN HHHCCCCCCCHHHCC		27149854
1150	Phosphorylation	EIPERTMSVSDFNYS HCCCCCCCHHHCCCC		25521595
1152	Phosphorylation	PERTMSVSDFNYSRT CCCCCCHHHCCCCCC		27149854
1156	Phosphorylation	MSVSDFNYSRTSPSK CCHHHCCCCCCCCCC		29514104
1157	Phosphorylation	SVSDFNYSRTSPSKR CHHHCCCCCCCCCCC		26643407
1159	Phosphorylation	SDFNYSRTSPSKRPN HHCCCCCCCCCCCCC		23984901
1160	Phosphorylation	DFNYSRTSPSKRPNT HCCCCCCCCCCCCCC		26643407
1162	Phosphorylation	NYSRTSPSKRPNTRV CCCCCCCCCCCCCCC		23984901
1171	Phosphorylation	RPNTRVGSEHSLLDP CCCCCCCCCCCCCCC		27087446
1174	Phosphorylation	TRVGSEHSLLDPPGK CCCCCCCCCCCCCCC		27149854
1207	Phosphorylation	KLEKHPQTSSPGECC HHHCCCCCCCCCCCC		25521595
1208	Phosphorylation	LEKHPQTSSPGECCQ HHCCCCCCCCCCCCC		29899451
1209	Phosphorylation	EKHPQTSSPGECCQD HCCCCCCCCCCCCCC		25195567
1209 (in isoform 2)	Phosphorylation	-		28066266
1212 (in isoform 2)	Phosphorylation	-		28066266
1218 (in isoform 2)	Phosphorylation	-		28066266
1219 (in isoform 2)	Phosphorylation	-		28066266
1220 (in isoform 2)	Phosphorylation	-		28066266
1222 (in isoform 2)	Phosphorylation	-		21183079
1224 (in isoform 2)	Phosphorylation	-		29472430
1225 (in isoform 2)	Phosphorylation	-		22817900
1231 (in isoform 2)	Phosphorylation	-		25521595
1234 (in isoform 2)	Phosphorylation	-		25521595
1238 (in isoform 2)	Phosphorylation	-		29472430
1239	Phosphorylation	SHRGLPDSLMKMPLS CCCCCCHHHHCCCCC		22802335
1245 (in isoform 2)	Phosphorylation	-		28066266
1246	Phosphorylation	SLMKMPLSNGQMGQP HHHCCCCCCCCCCCC		20469934
1250 (in isoform 1)	Phosphorylation	-		29514104
1257 (in isoform 1)	Phosphorylation	-		29514104
1260	Phosphorylation	PLRPQAHYSQTHHPP CCCCCCCCCCCCCCC		20469934
1261	Phosphorylation	LRPQAHYSQTHHPPQ CCCCCCCCCCCCCCC		20469934
1263	Phosphorylation	PQAHYSQTHHPPQAS CCCCCCCCCCCCCHH		20469934
1270	Phosphorylation	THHPPQASVARHPSR CCCCCCHHCCCCCCH		20469934
1276	Phosphorylation	ASVARHPSREQLIDY HHCCCCCCHHHHHHH		26824392
1283	Phosphorylation	SREQLIDYLMLKVAH CHHHHHHHHHHHHHC		26160508
1294	Phosphorylation	KVAHQPPYTHPHCSP HHHCCCCCCCCCCCC		29514104
1300	Phosphorylation	PYTHPHCSPRQGHEL CCCCCCCCCCCCCHH		25338131
1325	Phosphorylation	KDPELGFSISGGVGG CCCCCCCEECCCCCC		26824392
1371	Phosphorylation	KIIQANGYSFINIEH EEEEECCEEEEEECC		29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERBIN_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1231	S	Phosphorylation	Isoform 2 is phosphorylated on Ser-1231 and Ser-1234.	21183079
1234	S	Phosphorylation	Isoform 2 is phosphorylated on Ser-1231 and Ser-1234.	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERBIN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKP4_MOUSE	Pkp4	physical	11711544

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.