ERBB3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERBB3_RAT
• UniProt AC: Q62799
• Protein Name: Receptor tyrosine-protein kinase erbB-3
• Gene Name: Erbb3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1339
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5..
• Protein Sequence: MRATGTLQVLCFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLKFTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRVRGAEIVVKNNGANCPPCHEVCKGRCWGPGPDDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRRFNDSGACVPRCPEPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTFCVRACPPDKMEVDKHGLKMCEPCGGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNVDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPSEERLDIKYDRPLGECLAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCNGPELQDCLGQAEVLMSKPHLVIAVTVGLAVILMILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGTPPAAEPSVLTTKELQEAELEPELDLDLDLEAEEEGLATSLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSSLGEACLDSAVLGGREQFSRPISLHPIPRGRPASESSEGHVTGSEAELQEKVSVCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGASSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPPRPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGAGGDYAAMGACPAAEQGYEEMRAFQGPGHHAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	N-linked_Glycosylation	VMLNYNTNSSHALRQ EEEECCCCCHHHHHH	37.57	-
250	N-linked_Glycosylation	CFACRRFNDSGACVP CEECCCCCCCCCCCC	40.50	-
353	N-linked_Glycosylation	SNIDGFVNCTKILGN CCCCCEEEHHHHHCC	26.02	-
408	N-linked_Glycosylation	SWPPHMHNFSVFSNL CCCCCCCCEECEECC	24.26	-
414	N-linked_Glycosylation	HNFSVFSNLTTIGGR CCEECEECCEEECCH	29.91	-
437	N-linked_Glycosylation	LLIMKNLNVTSLGFR EEEEECCCCCEECCC	44.40	-
469	N-linked_Glycosylation	LCYHHSLNWTRLLRG EEEECCCCHHHHCCC	40.88	-
522	N-linked_Glycosylation	GQCLSCRNYSREGVC CCCCCCCCCCCCCEE	43.38	-
566	N-linked_Glycosylation	MEGTSTCNGSGSDAC CCCCCCCCCCCCCHH	47.99	-
616	N-linked_Glycosylation	ECRPCHENCTQGCNG CCCCCCCCCCCCCCC	15.52	-
678	Phosphorylation	NKRAMRRYLERGESI CHHHHHHHHHCCCCC	11.53	23984901
684	Phosphorylation	RYLERGESIEPLDPS HHHHCCCCCCCCCHH	34.77	29779826
691	Phosphorylation	SIEPLDPSEKANKVL CCCCCCHHHHHHHHH	51.93	23984901
693	Ubiquitination	EPLDPSEKANKVLAR CCCCHHHHHHHHHHH	62.69	-
871	Phosphorylation	LLHSEAKTPIKWMAL HCCCCCCCCCCEEEE	36.98	22817900
924	Ubiquitination	EIPDLLEKGERLAQP HCHHHHHHCCHHCCC	67.07	-
980	Phosphorylation	YLVIKRASGPGTPPA EEEEEECCCCCCCCC	49.94	29779826
984	Phosphorylation	KRASGPGTPPAAEPS EECCCCCCCCCCCCC	29.27	27097102
991	Phosphorylation	TPPAAEPSVLTTKEL CCCCCCCCCCCHHHH	22.67	28689409
994	Phosphorylation	AAEPSVLTTKELQEA CCCCCCCCHHHHHHC	33.40	28689409
1051	Phosphorylation	LLSPSSGYMPMNQSS CCCCCCCCCCCCHHH	10.45	11546794
1080	Phosphorylation	EQFSRPISLHPIPRG HHCCCCCCCCCCCCC	24.25	28689409
1091	Phosphorylation	IPRGRPASESSEGHV CCCCCCCCCCCCCCC	40.47	22673903
1093	Phosphorylation	RGRPASESSEGHVTG CCCCCCCCCCCCCCC	31.06	22673903
1094	Phosphorylation	GRPASESSEGHVTGS CCCCCCCCCCCCCCC	43.47	22673903
1099	Phosphorylation	ESSEGHVTGSEAELQ CCCCCCCCCCHHHHH	29.34	22673903
1101	Phosphorylation	SEGHVTGSEAELQEK CCCCCCCCHHHHHHH	25.03	28689409
1120	Phosphorylation	RSRSRSRSPRPRGDS CCCCCCCCCCCCCCC	26.89	22817900
1173	Phosphorylation	ASSSREGTLSSVGLS CCCCCCCCCCHHCHH	20.79	27097102
1175	Phosphorylation	SSREGTLSSVGLSSV CCCCCCCCHHCHHHC	23.86	27097102
1176	Phosphorylation	SREGTLSSVGLSSVL CCCCCCCHHCHHHCC	24.26	27097102
1180	Phosphorylation	TLSSVGLSSVLGTEE CCCHHCHHHCCCCCC	16.69	27097102
1181	Phosphorylation	LSSVGLSSVLGTEEE CCHHCHHHCCCCCCC	26.80	27097102
1185	Phosphorylation	GLSSVLGTEEEDEDE CHHHCCCCCCCCCHH	35.74	27097102
1194	Phosphorylation	EEDEDEEYEYMNRKR CCCCHHHHHHHHHHC	15.43	11546794
1219	Phosphorylation	GSLEELGYEYMDVGS CCHHHHCCEEEECCC	19.26	11546794
1257	Phosphorylation	GTTPDEDYEYMNRRR CCCCHHHHHHHHHCC	13.60	11546794
1273	Phosphorylation	AGGAGGDYAAMGACP CCCCCCCCHHHCCCC	10.27	11546794
1286	Phosphorylation	CPAAEQGYEEMRAFQ CCHHHHHHHHHHHHC	14.38	11546794
1312	Phosphorylation	ARLKTLRSLEATDSA HHHHHHHHHHCCCCC	33.40	22108457
1325	Phosphorylation	SAFDNPDYWHSRLFP CCCCCCCHHHHHHCC	13.28	30181290
1328	Phosphorylation	DNPDYWHSRLFPKAN CCCCHHHHHHCCHHH	19.28	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
871	T	Phosphorylation	Kinase	CDK5	Q03114	PSP
1120	S	Phosphorylation	Kinase	CDK5	Q03114	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERBB3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERBB3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL13A_HUMAN	RPL13A	physical	10095121
L1CAM_RAT	L1cam	physical	22815787

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.